The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital
Abstract Introduction This study aims to describe the demographic, clinical, laboratory, and ultrasonic characteristics of patients with psoriatic arthritis (PsA) in the Psoriatic Arthritis cohort of West China Hospital. Methods In this cross-sectional study, we included patients diagnosed with PsA...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2023-02-01
|
| Series: | Rheumatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40744-023-00537-1 |
| _version_ | 1797836257355628544 |
|---|---|
| author | Yiyi Wang Yue Xiao Furong Li Yuanxia Gu Min Yang Lingyan Zhang Jing Tang Wei Li |
| author_facet | Yiyi Wang Yue Xiao Furong Li Yuanxia Gu Min Yang Lingyan Zhang Jing Tang Wei Li |
| author_sort | Yiyi Wang |
| collection | DOAJ |
| description | Abstract Introduction This study aims to describe the demographic, clinical, laboratory, and ultrasonic characteristics of patients with psoriatic arthritis (PsA) in the Psoriatic Arthritis cohort of West China Hospital. Methods In this cross-sectional study, we included patients diagnosed with PsA according to the Classification Criteria for Psoriatic Arthritis, collected their demographic information, medical histories, and treatments, evaluated all domains (skin and nail lesions, tenderness, swelling, enthesitis, dactylitis, and axial arthritis) related to PsA, and then performed descriptive statistical analyses of all data. Results A total of 275 patients with PsA were included in this study. The ratio of male to female patients was 2.16:1. Skin lesions preceded arthritis in 86.5% of these patients with PsA with a mean interval of 10.1 years. The metacarpophalangeal (MCP) joints, proximal interphalangeal (PIP) joints of fingers, and sacroiliac joints are the most commonly involved sites of tenderness, swelling, and the spine, respectively. Among all comorbidities, fatty liver has the highest incidence with 33.1%. Finally, we noted that the mean disease duration of PsA was 4.2 years, suggesting a delay in the diagnosis of PsA. Conclusion Our study proposes that the prevalent population of PsA are male patients with psoriasis over 40 years of age who have a long disease course. For patients with PsA, MCP, PIP joints of fingers, and sacroiliac joints are the most frequently affected anatomical sites. With respect to comorbidities, the association between PsA and fatty liver and the underlying molecular mechanisms are worthy of further exploration. |
| first_indexed | 2024-04-09T15:05:48Z |
| format | Article |
| id | doaj.art-02ba0b4d780549fd8167dd3c6f7926d5 |
| institution | Directory Open Access Journal |
| issn | 2198-6576 2198-6584 |
| language | English |
| last_indexed | 2024-04-09T15:05:48Z |
| publishDate | 2023-02-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj.art-02ba0b4d780549fd8167dd3c6f7926d52023-04-30T11:27:52ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842023-02-0110377578410.1007/s40744-023-00537-1The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China HospitalYiyi Wang0Yue Xiao1Furong Li2Yuanxia Gu3Min Yang4Lingyan Zhang5Jing Tang6Wei Li7Department of Dermatology and Rare Diseases Center, West China Hospital, Sichuan UniversityDepartment of Dermatology and Rare Diseases Center, West China Hospital, Sichuan UniversityDepartment of Dermatology and Rare Diseases Center, West China Hospital, Sichuan UniversityDepartment of Dermatology and Rare Diseases Center, West China Hospital, Sichuan UniversityDepartment of Rheumatology, West China Hospital, Sichuan UniversityDepartment of Ultrasound, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Dermatology and Rare Diseases Center, West China Hospital, Sichuan UniversityAbstract Introduction This study aims to describe the demographic, clinical, laboratory, and ultrasonic characteristics of patients with psoriatic arthritis (PsA) in the Psoriatic Arthritis cohort of West China Hospital. Methods In this cross-sectional study, we included patients diagnosed with PsA according to the Classification Criteria for Psoriatic Arthritis, collected their demographic information, medical histories, and treatments, evaluated all domains (skin and nail lesions, tenderness, swelling, enthesitis, dactylitis, and axial arthritis) related to PsA, and then performed descriptive statistical analyses of all data. Results A total of 275 patients with PsA were included in this study. The ratio of male to female patients was 2.16:1. Skin lesions preceded arthritis in 86.5% of these patients with PsA with a mean interval of 10.1 years. The metacarpophalangeal (MCP) joints, proximal interphalangeal (PIP) joints of fingers, and sacroiliac joints are the most commonly involved sites of tenderness, swelling, and the spine, respectively. Among all comorbidities, fatty liver has the highest incidence with 33.1%. Finally, we noted that the mean disease duration of PsA was 4.2 years, suggesting a delay in the diagnosis of PsA. Conclusion Our study proposes that the prevalent population of PsA are male patients with psoriasis over 40 years of age who have a long disease course. For patients with PsA, MCP, PIP joints of fingers, and sacroiliac joints are the most frequently affected anatomical sites. With respect to comorbidities, the association between PsA and fatty liver and the underlying molecular mechanisms are worthy of further exploration.https://doi.org/10.1007/s40744-023-00537-1PsoriasisPsoriatic arthritisClinical studyChina |
| spellingShingle | Yiyi Wang Yue Xiao Furong Li Yuanxia Gu Min Yang Lingyan Zhang Jing Tang Wei Li The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital Rheumatology and Therapy Psoriasis Psoriatic arthritis Clinical study China |
| title | The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital |
| title_full | The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital |
| title_fullStr | The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital |
| title_full_unstemmed | The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital |
| title_short | The Clinical Characteristics of Psoriatic Arthritis: A Cross-Sectional Study Based on the Psoriatic Arthritis Cohort of West China Hospital |
| title_sort | clinical characteristics of psoriatic arthritis a cross sectional study based on the psoriatic arthritis cohort of west china hospital |
| topic | Psoriasis Psoriatic arthritis Clinical study China |
| url | https://doi.org/10.1007/s40744-023-00537-1 |
| work_keys_str_mv | AT yiyiwang theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT yuexiao theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT furongli theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT yuanxiagu theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT minyang theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT lingyanzhang theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT jingtang theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT weili theclinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT yiyiwang clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT yuexiao clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT furongli clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT yuanxiagu clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT minyang clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT lingyanzhang clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT jingtang clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital AT weili clinicalcharacteristicsofpsoriaticarthritisacrosssectionalstudybasedonthepsoriaticarthritiscohortofwestchinahospital |