Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation
The autonomic nervous system is crucial in initiating and maintaining atrial fibrillation (AF). Catestatin is a multipurpose peptide that regulates cardiovascular systems and reduces harmful, excessive activity of the sympathetic nervous system by blocking the release of catecholamines. We aimed to...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/2/85 |
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| author | Josip Katic Zrinka Jurisic Marko Kumric Josip A. Borovac Ante Anic Toni Breskovic Daniela Supe-Domic Josko Bozic |
| author_facet | Josip Katic Zrinka Jurisic Marko Kumric Josip A. Borovac Ante Anic Toni Breskovic Daniela Supe-Domic Josko Bozic |
| author_sort | Josip Katic |
| collection | DOAJ |
| description | The autonomic nervous system is crucial in initiating and maintaining atrial fibrillation (AF). Catestatin is a multipurpose peptide that regulates cardiovascular systems and reduces harmful, excessive activity of the sympathetic nervous system by blocking the release of catecholamines. We aimed to determine whether serum catestatin concentrations are associated with AF severity, duration indices, and various clinical and laboratory indicators in these individuals to better define the clinical value of catestatin in patients with AF. The present single center study enrolled 73 participants with AF and 72 healthy age-matched controls. Serum catestatin concentrations were markedly higher in AF patients than controls (14.11 (10.21–26.02) ng/mL vs. 10.93 (5.70–20.01) ng/mL, <i>p</i> = 0.013). Furthermore, patients with a more severe form of AF had significantly higher serum catestatin (17.56 (12.80–40.35) vs. 10.98 (8.38–20.91) ng/mL, <i>p =</i> 0.001). Patients with higher CHA<sub>2</sub>DS<sub>2</sub>-VASc scores (17.58 (11.89–37.87) vs. 13.02 (8.47–22.75) ng/mL, <i>p</i> = 0.034) and higher NT-proBNP levels (17.58 (IQR 13.91–34.62) vs. 13.23 (IQR 9.04–22.61), <i>p</i> = 0.036) had significantly higher serum catestatin concentrations. Finally, AF duration correlated negatively with serum catestatin levels (r = −0.348, <i>p</i> = 0.003). The results of the present study implicate the promising role of catestatin in the intricate pathophysiology of AF, which should be explored in future research. |
| first_indexed | 2024-03-11T08:38:18Z |
| format | Article |
| id | doaj.art-02ba42e96f7d4a78bada81b82a5a5ccd |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T08:38:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-02ba42e96f7d4a78bada81b82a5a5ccd2023-11-16T21:16:49ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-02-011028510.3390/jcdd10020085Serum Catestatin Concentrations Are Increased in Patients with Atrial FibrillationJosip Katic0Zrinka Jurisic1Marko Kumric2Josip A. Borovac3Ante Anic4Toni Breskovic5Daniela Supe-Domic6Josko Bozic7Department of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaThe autonomic nervous system is crucial in initiating and maintaining atrial fibrillation (AF). Catestatin is a multipurpose peptide that regulates cardiovascular systems and reduces harmful, excessive activity of the sympathetic nervous system by blocking the release of catecholamines. We aimed to determine whether serum catestatin concentrations are associated with AF severity, duration indices, and various clinical and laboratory indicators in these individuals to better define the clinical value of catestatin in patients with AF. The present single center study enrolled 73 participants with AF and 72 healthy age-matched controls. Serum catestatin concentrations were markedly higher in AF patients than controls (14.11 (10.21–26.02) ng/mL vs. 10.93 (5.70–20.01) ng/mL, <i>p</i> = 0.013). Furthermore, patients with a more severe form of AF had significantly higher serum catestatin (17.56 (12.80–40.35) vs. 10.98 (8.38–20.91) ng/mL, <i>p =</i> 0.001). Patients with higher CHA<sub>2</sub>DS<sub>2</sub>-VASc scores (17.58 (11.89–37.87) vs. 13.02 (8.47–22.75) ng/mL, <i>p</i> = 0.034) and higher NT-proBNP levels (17.58 (IQR 13.91–34.62) vs. 13.23 (IQR 9.04–22.61), <i>p</i> = 0.036) had significantly higher serum catestatin concentrations. Finally, AF duration correlated negatively with serum catestatin levels (r = −0.348, <i>p</i> = 0.003). The results of the present study implicate the promising role of catestatin in the intricate pathophysiology of AF, which should be explored in future research.https://www.mdpi.com/2308-3425/10/2/85catestatinatrial fibrillationautonomic nervous systematrial remodeling |
| spellingShingle | Josip Katic Zrinka Jurisic Marko Kumric Josip A. Borovac Ante Anic Toni Breskovic Daniela Supe-Domic Josko Bozic Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation Journal of Cardiovascular Development and Disease catestatin atrial fibrillation autonomic nervous system atrial remodeling |
| title | Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation |
| title_full | Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation |
| title_fullStr | Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation |
| title_full_unstemmed | Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation |
| title_short | Serum Catestatin Concentrations Are Increased in Patients with Atrial Fibrillation |
| title_sort | serum catestatin concentrations are increased in patients with atrial fibrillation |
| topic | catestatin atrial fibrillation autonomic nervous system atrial remodeling |
| url | https://www.mdpi.com/2308-3425/10/2/85 |
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