A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options
Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a v...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374236/full |
| _version_ | 1797238439846871040 |
|---|---|
| author | Fang Yuan Yanxia Hu Fei Xu Xujun Feng Xujun Feng |
| author_facet | Fang Yuan Yanxia Hu Fei Xu Xujun Feng Xujun Feng |
| author_sort | Fang Yuan |
| collection | DOAJ |
| description | Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been established biologically. The pathophysiological processes associated with OSA, such as sleep fragmentation, intermittent hypoxia, and increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate and cellular immunity), and ultimately contribute to the occurrence of lung cancer, accelerate progression, and induce treatment resistance. OSA may be a contributor to but a preventable cause of the progression of lung cancer. However, whether this effect exists independently of other risk factors is unclear. Therefore, by reviewing the literature on the epidemiology, pathogenesis, and treatment of lung cancer and OSA, we hope to understand the relationships between the two and promote the interdisciplinary exchange of ideas between basic medicine, clinical medicine, respiratory medicine, sleep medicine, and oncology. |
| first_indexed | 2024-04-24T17:35:40Z |
| format | Article |
| id | doaj.art-02bc666a13ea4b03bc96de4fbe15a5a9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T17:35:40Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-02bc666a13ea4b03bc96de4fbe15a5a92024-03-28T04:41:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13742361374236A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic optionsFang Yuan0Yanxia Hu1Fei Xu2Xujun Feng3Xujun Feng4Department of Respiratory, The First Hospital of Jiujiang City, Jiujiang, ChinaDepartment of Respiratory, The First Hospital of Jiujiang City, Jiujiang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Respiratory, The First Hospital of Jiujiang City, Jiujiang, ChinaDepartment of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaDespite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been established biologically. The pathophysiological processes associated with OSA, such as sleep fragmentation, intermittent hypoxia, and increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate and cellular immunity), and ultimately contribute to the occurrence of lung cancer, accelerate progression, and induce treatment resistance. OSA may be a contributor to but a preventable cause of the progression of lung cancer. However, whether this effect exists independently of other risk factors is unclear. Therefore, by reviewing the literature on the epidemiology, pathogenesis, and treatment of lung cancer and OSA, we hope to understand the relationships between the two and promote the interdisciplinary exchange of ideas between basic medicine, clinical medicine, respiratory medicine, sleep medicine, and oncology.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374236/fullobstructive sleep apnealung cancerintermittent hypoxiaepidemiologytumor associated macrophages |
| spellingShingle | Fang Yuan Yanxia Hu Fei Xu Xujun Feng Xujun Feng A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options Frontiers in Immunology obstructive sleep apnea lung cancer intermittent hypoxia epidemiology tumor associated macrophages |
| title | A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options |
| title_full | A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options |
| title_fullStr | A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options |
| title_full_unstemmed | A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options |
| title_short | A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options |
| title_sort | review of obstructive sleep apnea and lung cancer epidemiology pathogenesis and therapeutic options |
| topic | obstructive sleep apnea lung cancer intermittent hypoxia epidemiology tumor associated macrophages |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374236/full |
| work_keys_str_mv | AT fangyuan areviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT yanxiahu areviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT feixu areviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT xujunfeng areviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT xujunfeng areviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT fangyuan reviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT yanxiahu reviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT feixu reviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT xujunfeng reviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions AT xujunfeng reviewofobstructivesleepapneaandlungcancerepidemiologypathogenesisandtherapeuticoptions |