The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies
Abstract Introduction The aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe form of COVID‐19, and its associated complications. Methods This meta‐analysis employed a keyword search (COVID‐19 an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13552 |
| _version_ | 1811315812694228992 |
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| author | Maryam Afraie Pardis Mohammadzedeh Mobin Azami Sorour Khateri Kamran Zamani Farhad Moradpour Yousef Moradi |
| author_facet | Maryam Afraie Pardis Mohammadzedeh Mobin Azami Sorour Khateri Kamran Zamani Farhad Moradpour Yousef Moradi |
| author_sort | Maryam Afraie |
| collection | DOAJ |
| description | Abstract Introduction The aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe form of COVID‐19, and its associated complications. Methods This meta‐analysis employed a keyword search (COVID‐19 and chronic liver disorders) using PubMed (Medline), Scopus, Web of Sciences, and Embase (Elsevier). All articles related from January 2019 to May 2022 were reviewed. The STATA software was used for analysis. Results The risk of death in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46–1.57; I2: 86.14%). Also, the risk of acute respiratory distress syndrome (ARDS) and hospitalization in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease ([RR: 1.65; CI 95%: 1.09–2.50; I2: 0.00%] and [RR: 1.39; CI 95%: 1.23–1.58; I2: 0.20%]). Also, the meta‐analysis showed cough, headache, myalgia, nausea, diarrhea, and fatigue were 1.37 (CI 95%: 1.20–1.55), 1.23 (CI 95%: 1.09–1.38), 1.25 (CI 95%: 1.04–1.50), 1.19 (CI 95%: 1.02–1.40), 1.89 (CI 95%: 1.30–2.75), 1.49 (CI 95%: 1.07–2.09), and 1.14 (CI 95%: 0.98–1.33), respectively, whereas the risk of all these symptoms was higher in COVID‐19 patients with chronic liver diseases than ones without chronic liver disorders. Conclusion The mortality and complications due to COVID‐19 were significantly different between patients with the chronic liver disease and the general population. |
| first_indexed | 2024-04-13T11:38:02Z |
| format | Article |
| id | doaj.art-02bf112fa84a4b0bb46d8750ee60701d |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-04-13T11:38:02Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-02bf112fa84a4b0bb46d8750ee60701d2022-12-22T02:48:22ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2022-12-01161277779210.1111/crj.13552The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studiesMaryam Afraie0Pardis Mohammadzedeh1Mobin Azami2Sorour Khateri3Kamran Zamani4Farhad Moradpour5Yousef Moradi6Department of Epidemiology and Biostatistics, Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj IranDepartment of Epidemiology and Biostatistics, Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj IranStudent Research Committee Kurdistan University of Medical Sciences Sanandaj IranDepartment of Physical Medicine and Rehabilitation Hamedan University of Medical Sciences Hamedan IranStudent Research Committee Kurdistan University of Medical Sciences Sanandaj IranSocial Determinants of Health Research Center, Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj IranSocial Determinants of Health Research Center, Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj IranAbstract Introduction The aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe form of COVID‐19, and its associated complications. Methods This meta‐analysis employed a keyword search (COVID‐19 and chronic liver disorders) using PubMed (Medline), Scopus, Web of Sciences, and Embase (Elsevier). All articles related from January 2019 to May 2022 were reviewed. The STATA software was used for analysis. Results The risk of death in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46–1.57; I2: 86.14%). Also, the risk of acute respiratory distress syndrome (ARDS) and hospitalization in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease ([RR: 1.65; CI 95%: 1.09–2.50; I2: 0.00%] and [RR: 1.39; CI 95%: 1.23–1.58; I2: 0.20%]). Also, the meta‐analysis showed cough, headache, myalgia, nausea, diarrhea, and fatigue were 1.37 (CI 95%: 1.20–1.55), 1.23 (CI 95%: 1.09–1.38), 1.25 (CI 95%: 1.04–1.50), 1.19 (CI 95%: 1.02–1.40), 1.89 (CI 95%: 1.30–2.75), 1.49 (CI 95%: 1.07–2.09), and 1.14 (CI 95%: 0.98–1.33), respectively, whereas the risk of all these symptoms was higher in COVID‐19 patients with chronic liver diseases than ones without chronic liver disorders. Conclusion The mortality and complications due to COVID‐19 were significantly different between patients with the chronic liver disease and the general population.https://doi.org/10.1111/crj.13552chronic liver diseasecomplicationsCOVID‐19meta‐analysismortality |
| spellingShingle | Maryam Afraie Pardis Mohammadzedeh Mobin Azami Sorour Khateri Kamran Zamani Farhad Moradpour Yousef Moradi The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies The Clinical Respiratory Journal chronic liver disease complications COVID‐19 meta‐analysis mortality |
| title | The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
| title_full | The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
| title_fullStr | The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
| title_full_unstemmed | The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
| title_short | The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies |
| title_sort | association of chronic liver disorders with exacerbation of symptoms and complications related to covid 19 a systematic review and meta analysis of cohort studies |
| topic | chronic liver disease complications COVID‐19 meta‐analysis mortality |
| url | https://doi.org/10.1111/crj.13552 |
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