The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission
AbstractPurpose Due to the poor and unpredictable prognosis of breast cancer (BC) patients with bone metastasis, it is necessary to find convenient and available prognostic predictors. This study aimed to recognize the clinical and prognostic factors related to clinical laboratory examination and to...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2231342 |
| _version_ | 1797353709821231104 |
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| author | Bo Huang Fang-Cai Wu Wei-Dong Wang Bu-Qing Shao Xiao-Mei Wang Ying-Miao Lin Guo-Xing Zheng Ming-Ming Dong Can-Tong Liu Yi-Wei Xu Xin-Jia Wang |
| author_facet | Bo Huang Fang-Cai Wu Wei-Dong Wang Bu-Qing Shao Xiao-Mei Wang Ying-Miao Lin Guo-Xing Zheng Ming-Ming Dong Can-Tong Liu Yi-Wei Xu Xin-Jia Wang |
| author_sort | Bo Huang |
| collection | DOAJ |
| description | AbstractPurpose Due to the poor and unpredictable prognosis of breast cancer (BC) patients with bone metastasis, it is necessary to find convenient and available prognostic predictors. This study aimed to recognize the clinical and prognostic factors related to clinical laboratory examination and to construct a prognostic nomogram for BC bone metastasis.Methods We retrospectively analyzed 32 candidate indicators from clinical features and laboratory examination data of 276 BC patients with bone metastasis. Univariate and multivariate regression analyses were performed to identify significant prognostic factors related to BC with bone metastasis. Nomogram was constructed and estimated by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis.Results Patients were randomly grouped into training (n = 197) and validation cohorts (n = 79). In training cohort, the multivariate regression analysis revealed that age, other organ metastasis sites, serum level of lactate dehydrogenase, globulin, white blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, and monocyte ratio were independent prognostic factors for BC with bone metastasis. The prognostic nomogram in training cohort exhibited areas under the ROC curve (AUCs) of 0.797, 0.782, and 0.794, respectively, for predicting 1-, 3-, and 5-year overall survival. In validation cohort, the nomogram still showed acceptable discrimination ability (AUCs: 0.723, 0.742, and 0.704) and calibration.Conclusion This study constructed a novel prognostic nomogram for BC patients with bone metastasis. It could serve as a potential tool of survival assessment to help individual treatment decision-making for clinicians. |
| first_indexed | 2024-03-08T13:34:58Z |
| format | Article |
| id | doaj.art-02c10c677496477a9965a8c199a37809 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:58Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-02c10c677496477a9965a8c199a378092024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2231342The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admissionBo Huang0Fang-Cai Wu1Wei-Dong Wang2Bu-Qing Shao3Xiao-Mei Wang4Ying-Miao Lin5Guo-Xing Zheng6Ming-Ming Dong7Can-Tong Liu8Yi-Wei Xu9Xin-Jia Wang10Department of Orthopedics, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiation Oncology, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Orthopedics, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Orthopedics, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Orthopedics, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaEsophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, Shantou, ChinaEsophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Orthopedics, The Cancer Hospital of Shantou University Medical College, Shantou, ChinaAbstractPurpose Due to the poor and unpredictable prognosis of breast cancer (BC) patients with bone metastasis, it is necessary to find convenient and available prognostic predictors. This study aimed to recognize the clinical and prognostic factors related to clinical laboratory examination and to construct a prognostic nomogram for BC bone metastasis.Methods We retrospectively analyzed 32 candidate indicators from clinical features and laboratory examination data of 276 BC patients with bone metastasis. Univariate and multivariate regression analyses were performed to identify significant prognostic factors related to BC with bone metastasis. Nomogram was constructed and estimated by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis.Results Patients were randomly grouped into training (n = 197) and validation cohorts (n = 79). In training cohort, the multivariate regression analysis revealed that age, other organ metastasis sites, serum level of lactate dehydrogenase, globulin, white blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, and monocyte ratio were independent prognostic factors for BC with bone metastasis. The prognostic nomogram in training cohort exhibited areas under the ROC curve (AUCs) of 0.797, 0.782, and 0.794, respectively, for predicting 1-, 3-, and 5-year overall survival. In validation cohort, the nomogram still showed acceptable discrimination ability (AUCs: 0.723, 0.742, and 0.704) and calibration.Conclusion This study constructed a novel prognostic nomogram for BC patients with bone metastasis. It could serve as a potential tool of survival assessment to help individual treatment decision-making for clinicians.https://www.tandfonline.com/doi/10.1080/07853890.2023.2231342Breast cancerbone metastasisprognosisnomogramblood routine and biochemical examination |
| spellingShingle | Bo Huang Fang-Cai Wu Wei-Dong Wang Bu-Qing Shao Xiao-Mei Wang Ying-Miao Lin Guo-Xing Zheng Ming-Ming Dong Can-Tong Liu Yi-Wei Xu Xin-Jia Wang The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission Annals of Medicine Breast cancer bone metastasis prognosis nomogram blood routine and biochemical examination |
| title | The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| title_full | The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| title_fullStr | The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| title_full_unstemmed | The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| title_short | The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| title_sort | prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission |
| topic | Breast cancer bone metastasis prognosis nomogram blood routine and biochemical examination |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2231342 |
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