Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand
The coupling of the neuronal energetics to the blood-oxygen-level-dependent (BOLD) response is still incompletely understood. To address this issue, we compared the fits of four plausible models of neurometabolic coupling dynamics to available data for simultaneous recordings of the local field pote...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00419/full |
| _version_ | 1818900198841122816 |
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| author | Christopher W Tyler Lora T Likova Spero eNicholas |
| author_facet | Christopher W Tyler Lora T Likova Spero eNicholas |
| author_sort | Christopher W Tyler |
| collection | DOAJ |
| description | The coupling of the neuronal energetics to the blood-oxygen-level-dependent (BOLD) response is still incompletely understood. To address this issue, we compared the fits of four plausible models of neurometabolic coupling dynamics to available data for simultaneous recordings of the local field potential (LFP) and the local BOLD response recorded from monkey primary visual cortex over a wide range of stimulus durations. The four models of the metabolic demand driving the BOLD response were: direct coupling with the overall LFP; rectified coupling to the LFP; coupling with a slow adaptive component of the implied neural population response; and coupling with the non-adaptive intracellular input signal defined by the stimulus time course. Taking all stimulus durations into account, the results imply that the BOLD response is most closely coupled with metabolic demand derived from the intracellular input waveform, without significant influence from the adaptive transients and nonlinearities exhibited by the LFP waveform. |
| first_indexed | 2024-12-19T20:00:03Z |
| format | Article |
| id | doaj.art-02c45881e1fd415aa794a11320baf76c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T20:00:03Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-02c45881e1fd415aa794a11320baf76c2022-12-21T20:07:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-12-01910.3389/fnins.2015.0041996237Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic DemandChristopher W Tyler0Lora T Likova1Spero eNicholas2Smith-Kettlewell Eye Research InstituteSmith-Kettlewell Eye Research InstituteSmith-Kettlewell Eye Research InstituteThe coupling of the neuronal energetics to the blood-oxygen-level-dependent (BOLD) response is still incompletely understood. To address this issue, we compared the fits of four plausible models of neurometabolic coupling dynamics to available data for simultaneous recordings of the local field potential (LFP) and the local BOLD response recorded from monkey primary visual cortex over a wide range of stimulus durations. The four models of the metabolic demand driving the BOLD response were: direct coupling with the overall LFP; rectified coupling to the LFP; coupling with a slow adaptive component of the implied neural population response; and coupling with the non-adaptive intracellular input signal defined by the stimulus time course. Taking all stimulus durations into account, the results imply that the BOLD response is most closely coupled with metabolic demand derived from the intracellular input waveform, without significant influence from the adaptive transients and nonlinearities exhibited by the LFP waveform.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00419/fullfMRIhuman brainLocal Field PotentialsMultimodal ImagingBOLDmetabolic coupling |
| spellingShingle | Christopher W Tyler Lora T Likova Spero eNicholas Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand Frontiers in Neuroscience fMRI human brain Local Field Potentials Multimodal Imaging BOLD metabolic coupling |
| title | Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand |
| title_full | Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand |
| title_fullStr | Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand |
| title_full_unstemmed | Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand |
| title_short | Analysis of Neural-BOLD Coupling through Four Models of the Neural Metabolic Demand |
| title_sort | analysis of neural bold coupling through four models of the neural metabolic demand |
| topic | fMRI human brain Local Field Potentials Multimodal Imaging BOLD metabolic coupling |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00419/full |
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