KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia

KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia

Background/Aims: It has been demonstrated that KRAS mutations represent about 90% of cancer-associated mutations, and that KRAS mutations play an essential role in neoplastic transformation. Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML), suggesting a functional rol...

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Bibliographic Details
Main Authors: Shanmin Zhao, Yuxia Zhang, Kun Sha, Qiu Tang, Xiaohua Yang, Chenlin Yu, Zhixue Liu, Wei Sun, Liping Cai, Chen Xu, Shufang Cui
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ras mutations
Acute myeloid leukemia
Leukemogenesis
K-ras
AML1/ETO
Online Access:http://www.karger.com/Article/FullText/356651

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