Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

Abstract Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs. Carvedilol (CAR), a nonselective beta/alpha1 blocker, used in the treatment of m...

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Bibliographic Details
Main Authors: Shivarani Eesam, Jaswanth S. Bhandaru, Chandana Naliganti, Ravi Kumar Bobbala, Raghuram Rao Akkinepally
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Carvedilol
Hydrochlorothiazide
Solubility
Dissolution rate
Cocrystallization
Online Access:http://link.springer.com/article/10.1186/s43094-020-00083-5

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