A case of angioedema of hereditary origin in a rural clinic near Subotica
Introduction: Hereditary angioedema (HAE) is inherited in an autosomal dominant manner. It manifests with bradykinin-mediated swelling due to a deficiency of C1 inhibitor. Managing these patients is challenging during acute edema and the onset of asphyxiation. Transportation to the hospital takes 25...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society, Department of Emergency Medicine, Belgrade
2023-01-01
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| Series: | ABC: časopis urgentne medicine |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1451-1053/2023/1451-10532302007G.pdf |
| _version_ | 1797265090888597504 |
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| author | Gavrilović Nikola Momirović-Stojković Milena Budimski-Soldat Mihaela |
| author_facet | Gavrilović Nikola Momirović-Stojković Milena Budimski-Soldat Mihaela |
| author_sort | Gavrilović Nikola |
| collection | DOAJ |
| description | Introduction: Hereditary angioedema (HAE) is inherited in an autosomal dominant manner. It manifests with bradykinin-mediated swelling due to a deficiency of C1 inhibitor. Managing these patients is challenging during acute edema and the onset of asphyxiation. Transportation to the hospital takes 25 minutes. Objective: To present a patient with HAE for whom specific therapy has only recently become available. Case Presentation: A female patient presented with difficulty breathing, swelling of the lips, and periorbital edema. Status: visibly distressed, talkative, facial and lip swelling, visible mucosa without edema, uvula and pharynx calm. Respiratory movements symmetric, without the use of accessory muscles. Auscultation revealed normal breath sounds, tachycardic heart action, clear tones without murmurs, and no urticaria. Blood pressure 120/70 mmHg, heart rate 100/min., respiratory rate 30/min., SpO2 98%, capillary refill time (CRT) 2 sec. Treatment: infusion, Methylprednisolone 40 mg IV. She was transported with monitoring. During transport, the condition worsened: blood pressure 105/60 mmHg, heart rate 130/min., respiratory rate 40/min., SpO2 94%, CRT 2 sec. Oxygen at 15 L/min. was initiated, an additional IV line was opened, and capnography showed ETCO2 of 36 mmHg. Methylprednisolone was increased to 80 mg. Preparation for difficult intubation was initiated. Parameters did not worsen, and the patient was transferred to the emergency department of the General Hospital Subotica. Conclusion: Since specific therapies, such as human C1 inhibitor concentrate or bradykinin receptor antagonists, have been approved for self-administration at home during acute attacks, the treatment of these patients has been facilitated, minimizing the potential fatal outcomes and morbidity. |
| first_indexed | 2024-04-25T00:39:16Z |
| format | Article |
| id | doaj.art-02c4ec1b99d24086b9e40330f02f8996 |
| institution | Directory Open Access Journal |
| issn | 1451-1053 2560-3922 |
| language | English |
| last_indexed | 2024-04-25T00:39:16Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society, Department of Emergency Medicine, Belgrade |
| record_format | Article |
| series | ABC: časopis urgentne medicine |
| spelling | doaj.art-02c4ec1b99d24086b9e40330f02f89962024-03-12T12:04:13ZengSerbian Medical Society, Department of Emergency Medicine, BelgradeABC: časopis urgentne medicine1451-10532560-39222023-01-0123271110.5937/abc2302007G1451-10532302007GA case of angioedema of hereditary origin in a rural clinic near SuboticaGavrilović Nikola0Momirović-Stojković Milena1Budimski-Soldat Mihaela2Dom zdravlja, Subotica, SerbiaDom zdravlja, Subotica, SerbiaDom zdravlja, Subotica, SerbiaIntroduction: Hereditary angioedema (HAE) is inherited in an autosomal dominant manner. It manifests with bradykinin-mediated swelling due to a deficiency of C1 inhibitor. Managing these patients is challenging during acute edema and the onset of asphyxiation. Transportation to the hospital takes 25 minutes. Objective: To present a patient with HAE for whom specific therapy has only recently become available. Case Presentation: A female patient presented with difficulty breathing, swelling of the lips, and periorbital edema. Status: visibly distressed, talkative, facial and lip swelling, visible mucosa without edema, uvula and pharynx calm. Respiratory movements symmetric, without the use of accessory muscles. Auscultation revealed normal breath sounds, tachycardic heart action, clear tones without murmurs, and no urticaria. Blood pressure 120/70 mmHg, heart rate 100/min., respiratory rate 30/min., SpO2 98%, capillary refill time (CRT) 2 sec. Treatment: infusion, Methylprednisolone 40 mg IV. She was transported with monitoring. During transport, the condition worsened: blood pressure 105/60 mmHg, heart rate 130/min., respiratory rate 40/min., SpO2 94%, CRT 2 sec. Oxygen at 15 L/min. was initiated, an additional IV line was opened, and capnography showed ETCO2 of 36 mmHg. Methylprednisolone was increased to 80 mg. Preparation for difficult intubation was initiated. Parameters did not worsen, and the patient was transferred to the emergency department of the General Hospital Subotica. Conclusion: Since specific therapies, such as human C1 inhibitor concentrate or bradykinin receptor antagonists, have been approved for self-administration at home during acute attacks, the treatment of these patients has been facilitated, minimizing the potential fatal outcomes and morbidity.https://scindeks-clanci.ceon.rs/data/pdf/1451-1053/2023/1451-10532302007G.pdfangioedemashereditaryemergency medical servicesemergency medicinerural health center |
| spellingShingle | Gavrilović Nikola Momirović-Stojković Milena Budimski-Soldat Mihaela A case of angioedema of hereditary origin in a rural clinic near Subotica ABC: časopis urgentne medicine angioedemas hereditary emergency medical services emergency medicine rural health center |
| title | A case of angioedema of hereditary origin in a rural clinic near Subotica |
| title_full | A case of angioedema of hereditary origin in a rural clinic near Subotica |
| title_fullStr | A case of angioedema of hereditary origin in a rural clinic near Subotica |
| title_full_unstemmed | A case of angioedema of hereditary origin in a rural clinic near Subotica |
| title_short | A case of angioedema of hereditary origin in a rural clinic near Subotica |
| title_sort | case of angioedema of hereditary origin in a rural clinic near subotica |
| topic | angioedemas hereditary emergency medical services emergency medicine rural health center |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1451-1053/2023/1451-10532302007G.pdf |
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