Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response
Circulating lipids can influence immune cell function, which could have implications for inflammatory diseases such as rheumatoid arthritis. Here, the authors use Mendelian randomization to identify genes whose expression is influenced by triglyceride levels in blood, implicating genes involved in l...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35663-x |
| _version_ | 1811171603698941952 |
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| author | Koen F. Dekkers Roderick C. Slieker Andreea Ioan-Facsinay Maarten van Iterson BIOS consortium M. Arfan Ikram Marleen M. J. van Greevenbroek Jan H. Veldink Lude Franke Dorret I. Boomsma P. Eline Slagboom J. Wouter Jukema Bastiaan T. Heijmans |
| author_facet | Koen F. Dekkers Roderick C. Slieker Andreea Ioan-Facsinay Maarten van Iterson BIOS consortium M. Arfan Ikram Marleen M. J. van Greevenbroek Jan H. Veldink Lude Franke Dorret I. Boomsma P. Eline Slagboom J. Wouter Jukema Bastiaan T. Heijmans |
| author_sort | Koen F. Dekkers |
| collection | DOAJ |
| description | Circulating lipids can influence immune cell function, which could have implications for inflammatory diseases such as rheumatoid arthritis. Here, the authors use Mendelian randomization to identify genes whose expression is influenced by triglyceride levels in blood, implicating genes involved in lipid metabolism and allergic response. |
| first_indexed | 2024-04-10T17:16:49Z |
| format | Article |
| id | doaj.art-02c53d21682b4b45ae7d306815c8b2c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T17:16:49Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-02c53d21682b4b45ae7d306815c8b2c42023-02-05T12:18:00ZengNature PortfolioNature Communications2041-17232023-02-011411910.1038/s41467-022-35663-xLipid-induced transcriptomic changes in blood link to lipid metabolism and allergic responseKoen F. Dekkers0Roderick C. Slieker1Andreea Ioan-Facsinay2Maarten van Iterson3BIOS consortiumM. Arfan Ikram4Marleen M. J. van Greevenbroek5Jan H. Veldink6Lude Franke7Dorret I. Boomsma8P. Eline Slagboom9J. Wouter Jukema10Bastiaan T. Heijmans11Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical CenterDepartment of Cell and Chemical Biology, Leiden University Medical CenterDepartment of Rheumatology, Leiden University Medical CenterMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical CenterDepartment of Epidemiology, Erasmus MCDepartment of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical CenterDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht UniversityDepartment of Genetics, University Medical Center GroningenDepartment of Biological Psychology, Vrije Universiteit AmsterdamMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical CenterDepartment of Cardiology, Leiden University Medical CenterMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical CenterCirculating lipids can influence immune cell function, which could have implications for inflammatory diseases such as rheumatoid arthritis. Here, the authors use Mendelian randomization to identify genes whose expression is influenced by triglyceride levels in blood, implicating genes involved in lipid metabolism and allergic response.https://doi.org/10.1038/s41467-022-35663-x |
| spellingShingle | Koen F. Dekkers Roderick C. Slieker Andreea Ioan-Facsinay Maarten van Iterson BIOS consortium M. Arfan Ikram Marleen M. J. van Greevenbroek Jan H. Veldink Lude Franke Dorret I. Boomsma P. Eline Slagboom J. Wouter Jukema Bastiaan T. Heijmans Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response Nature Communications |
| title | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| title_full | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| title_fullStr | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| title_full_unstemmed | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| title_short | Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| title_sort | lipid induced transcriptomic changes in blood link to lipid metabolism and allergic response |
| url | https://doi.org/10.1038/s41467-022-35663-x |
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