Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies against BRCA1/2‐mutated tumours exploit this vulnerability...

Полное описание

Библиографические подробности
Главные авторы: Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Формат: Статья
Язык:English
Опубликовано: Springer Nature 2022-02-01
Серии:EMBO Molecular Medicine
Предметы:
BRCA1
BRCA2
DNA damage responses
G‐quadruplex ligands
pyridostatin
Online-ссылка:https://doi.org/10.15252/emmm.202114501

Internet

https://doi.org/10.15252/emmm.202114501

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