Potential Vaccines for Treating Crohn\'s Disease
Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Pasteur Institute of Iran
2020-01-01
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| Series: | Iranian Biomedical Journal |
| Subjects: | |
| Online Access: | http://ibj.pasteur.ac.ir/article-1-2878-en.html |
| _version_ | 1818264128568950784 |
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| author | Mohammad Rostami-Nejad Mohammad Hossein Yazdi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi |
| author_facet | Mohammad Rostami-Nejad Mohammad Hossein Yazdi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi |
| author_sort | Mohammad Rostami-Nejad |
| collection | DOAJ |
| description | Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium in CD. Apart from different therapeutic approaches for treating CD, development of a vaccine is a novel modality. In the present article, most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed. According to the search, availability of a new generation of vaccines against CD is expected specially tolerogenic ex vivo-derived DC-based vaccines. Regarding different locations of the challenge and the variety of clinical manifests of CD and also the type of resident antigen-presenting cells and their traffic in different parts of GIT, the results of immunotherapy with DC-based vaccines may vary case by case. |
| first_indexed | 2024-12-12T19:29:59Z |
| format | Article |
| id | doaj.art-02c67d04b4e140b498562e8bc6b59e22 |
| institution | Directory Open Access Journal |
| issn | 1028-852X 2008-823X |
| language | English |
| last_indexed | 2024-12-12T19:29:59Z |
| publishDate | 2020-01-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Iranian Biomedical Journal |
| spelling | doaj.art-02c67d04b4e140b498562e8bc6b59e222022-12-22T00:14:26ZengPasteur Institute of IranIranian Biomedical Journal1028-852X2008-823X2020-01-01241114Potential Vaccines for Treating Crohn\'s DiseaseMohammad Rostami-Nejad0Mohammad Hossein Yazdi1Shekoufeh Nikfar2Ali Rezaie3Mohammad Abdollahi4 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran Cedars-Sinai Medical Center, Los Angeles, CA, USA Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium in CD. Apart from different therapeutic approaches for treating CD, development of a vaccine is a novel modality. In the present article, most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed. According to the search, availability of a new generation of vaccines against CD is expected specially tolerogenic ex vivo-derived DC-based vaccines. Regarding different locations of the challenge and the variety of clinical manifests of CD and also the type of resident antigen-presenting cells and their traffic in different parts of GIT, the results of immunotherapy with DC-based vaccines may vary case by case.http://ibj.pasteur.ac.ir/article-1-2878-en.htmlcrohn’s diseaseinflammatory bowel diseasesvaccines |
| spellingShingle | Mohammad Rostami-Nejad Mohammad Hossein Yazdi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi Potential Vaccines for Treating Crohn\'s Disease Iranian Biomedical Journal crohn’s disease inflammatory bowel diseases vaccines |
| title | Potential Vaccines for Treating Crohn\'s Disease |
| title_full | Potential Vaccines for Treating Crohn\'s Disease |
| title_fullStr | Potential Vaccines for Treating Crohn\'s Disease |
| title_full_unstemmed | Potential Vaccines for Treating Crohn\'s Disease |
| title_short | Potential Vaccines for Treating Crohn\'s Disease |
| title_sort | potential vaccines for treating crohn s disease |
| topic | crohn’s disease inflammatory bowel diseases vaccines |
| url | http://ibj.pasteur.ac.ir/article-1-2878-en.html |
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