Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study
Abstract Objective To evaluate and compare the prevalence of structural congenital anomalies (CAs) according to maternal body mass index (BMI). Methods The present cross-sectional study involved pregnant women with fetuses diagnosed with structural CAs through morphological ultrasonography bet...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032019000500280&lng=en&tlng=en |
| _version_ | 1819023751231045632 |
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| author | Carolina Leão de Moraes Carolina Rodrigues Mendonça Natália Cruz e Melo Waldemar Naves do Amaral |
| author_facet | Carolina Leão de Moraes Carolina Rodrigues Mendonça Natália Cruz e Melo Waldemar Naves do Amaral |
| author_sort | Carolina Leão de Moraes |
| collection | DOAJ |
| description | Abstract Objective To evaluate and compare the prevalence of structural congenital anomalies (CAs) according to maternal body mass index (BMI). Methods The present cross-sectional study involved pregnant women with fetuses
diagnosed with structural CAs through morphological ultrasonography between November 2014 and January 2016. The nutritional status of the pregnant women was classified according to the gross value of the body mass index. The pregnant women were
categorized into four groups: low weight, adequate weight, overweight, and obesity. Statistical analysis was performed using Stata/SE version 12.0 (Stata Corporation, College Station, TX), with values of p ≤ 0.05 considered statistically significant.
Results A total of 223 pregnant women had fetuses diagnosed with CAs. The prevalence of structural CAs in pregnant women with lowweight was of 20.18%, of 43.50% in pregnant women with adequate weight, of 22.87% in pregnant women with overweight, and
of 13.45% in pregnant women with obesity. The prevalence of central nervous system (CNS) anomalies and of genitourinary systemanomalieswas high for the four groups of pregnant women. A positive association was observed between multiple anomalies in
pregnant women with adequate weight (prevalence ratio [PR] = 1.65; p ≤ 0.004) and between anomalies of the lymphatic system in obese pregnant women (PR = 4.04, p ≤ 0.000). Conclusion The prevalence of CNS and genitourinary systemanomalies was high in
all of the BMI categories. Obese pregnancies were associated with lymphatic system anomalies. Therefore, screening and identification of the risk factors for CAs are important, regardless of the maternal BMI. Our findings reinforce the importance of
discussing with pregnant women maternal nutrition and its effect on fetal development and on neonatal outcome. |
| first_indexed | 2024-12-21T04:43:52Z |
| format | Article |
| id | doaj.art-02c6840c7e164babb20d3b6ce52f31bf |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-12-21T04:43:52Z |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-02c6840c7e164babb20d3b6ce52f31bf2022-12-21T19:15:36ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-720341528029010.1055/s-0039-1683971S0100-72032019000500280Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional StudyCarolina Leão de MoraesCarolina Rodrigues MendonçaNatália Cruz e MeloWaldemar Naves do AmaralAbstract Objective To evaluate and compare the prevalence of structural congenital anomalies (CAs) according to maternal body mass index (BMI). Methods The present cross-sectional study involved pregnant women with fetuses diagnosed with structural CAs through morphological ultrasonography between November 2014 and January 2016. The nutritional status of the pregnant women was classified according to the gross value of the body mass index. The pregnant women were categorized into four groups: low weight, adequate weight, overweight, and obesity. Statistical analysis was performed using Stata/SE version 12.0 (Stata Corporation, College Station, TX), with values of p ≤ 0.05 considered statistically significant. Results A total of 223 pregnant women had fetuses diagnosed with CAs. The prevalence of structural CAs in pregnant women with lowweight was of 20.18%, of 43.50% in pregnant women with adequate weight, of 22.87% in pregnant women with overweight, and of 13.45% in pregnant women with obesity. The prevalence of central nervous system (CNS) anomalies and of genitourinary systemanomalieswas high for the four groups of pregnant women. A positive association was observed between multiple anomalies in pregnant women with adequate weight (prevalence ratio [PR] = 1.65; p ≤ 0.004) and between anomalies of the lymphatic system in obese pregnant women (PR = 4.04, p ≤ 0.000). Conclusion The prevalence of CNS and genitourinary systemanomalies was high in all of the BMI categories. Obese pregnancies were associated with lymphatic system anomalies. Therefore, screening and identification of the risk factors for CAs are important, regardless of the maternal BMI. Our findings reinforce the importance of discussing with pregnant women maternal nutrition and its effect on fetal development and on neonatal outcome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032019000500280&lng=en&tlng=encongenital anomaliespregnancyobesitybody weightfetal ultrasonography |
| spellingShingle | Carolina Leão de Moraes Carolina Rodrigues Mendonça Natália Cruz e Melo Waldemar Naves do Amaral Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study Revista Brasileira de Ginecologia e Obstetrícia congenital anomalies pregnancy obesity body weight fetal ultrasonography |
| title | Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study |
| title_full | Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study |
| title_fullStr | Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study |
| title_full_unstemmed | Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study |
| title_short | Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study |
| title_sort | prevalence and association of congenital anomalies according to the maternal body mass index cross sectional study |
| topic | congenital anomalies pregnancy obesity body weight fetal ultrasonography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032019000500280&lng=en&tlng=en |
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