Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have been widely used in the treatment of locally advanced non-small cell lung cancer (NSCLC). The phenomenon of pseudoprogression in targeted therapy in EGFR-mutation NSCLC patients is rare. Here, we reported an EGFR-mutation-p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.971192/full |
| _version_ | 1828147992909053952 |
|---|---|
| author | Fei Ren Yao Wang Yongsheng Gao Xiangjiao Meng Xiangjiao Meng |
| author_facet | Fei Ren Yao Wang Yongsheng Gao Xiangjiao Meng Xiangjiao Meng |
| author_sort | Fei Ren |
| collection | DOAJ |
| description | Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have been widely used in the treatment of locally advanced non-small cell lung cancer (NSCLC). The phenomenon of pseudoprogression in targeted therapy in EGFR-mutation NSCLC patients is rare. Here, we reported an EGFR-mutation-positive lung adenocarcinoma patient who was admitted to a hospital for cough and chest distress accompanied by shortness of breath. He underwent four cycles of chemotherapy with pemetrexed combined with carboplatin and concurrent radiotherapy in the third and fourth cycles. Then, he was treated by osimertinib maintenance therapy. After 11.5 months of osimertinib treatment, he was assessed to progressive disease by computed tomography. He underwent fiber bronchoscopy, and the biopsy pathology showed extensive necrosis without tumor cells. Until now, the patient has continued on osimertinib for 7 months without relapse or metastasis. As far as we know, we are the first to report pseudoprogression in osimertinib maintenance after definitive chemoradiation. This study reminds the clinicians to distinguish pseudoprogression from osimertinib-induced progression and avoid abandoning effective treatments. |
| first_indexed | 2024-04-11T21:08:28Z |
| format | Article |
| id | doaj.art-02c6969f6d35456e8438975da2b2b248 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T21:08:28Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-02c6969f6d35456e8438975da2b2b2482022-12-22T04:03:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.971192971192Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case reportFei Ren0Yao Wang1Yongsheng Gao2Xiangjiao Meng3Xiangjiao Meng4Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute Affiliated to Shandong University, Jinan, ChinaEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have been widely used in the treatment of locally advanced non-small cell lung cancer (NSCLC). The phenomenon of pseudoprogression in targeted therapy in EGFR-mutation NSCLC patients is rare. Here, we reported an EGFR-mutation-positive lung adenocarcinoma patient who was admitted to a hospital for cough and chest distress accompanied by shortness of breath. He underwent four cycles of chemotherapy with pemetrexed combined with carboplatin and concurrent radiotherapy in the third and fourth cycles. Then, he was treated by osimertinib maintenance therapy. After 11.5 months of osimertinib treatment, he was assessed to progressive disease by computed tomography. He underwent fiber bronchoscopy, and the biopsy pathology showed extensive necrosis without tumor cells. Until now, the patient has continued on osimertinib for 7 months without relapse or metastasis. As far as we know, we are the first to report pseudoprogression in osimertinib maintenance after definitive chemoradiation. This study reminds the clinicians to distinguish pseudoprogression from osimertinib-induced progression and avoid abandoning effective treatments.https://www.frontiersin.org/articles/10.3389/fonc.2022.971192/fullpseudoprogressionosimertinibEGFR mutationNSCLCcase report |
| spellingShingle | Fei Ren Yao Wang Yongsheng Gao Xiangjiao Meng Xiangjiao Meng Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report Frontiers in Oncology pseudoprogression osimertinib EGFR mutation NSCLC case report |
| title | Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report |
| title_full | Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report |
| title_fullStr | Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report |
| title_full_unstemmed | Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report |
| title_short | Pseudo-progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage III non-small cell lung cancer: A case report |
| title_sort | pseudo progression with osimertinib after definitive chemoradiation in unresectable epidermal growth factor receptor mutation positive of stage iii non small cell lung cancer a case report |
| topic | pseudoprogression osimertinib EGFR mutation NSCLC case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.971192/full |
| work_keys_str_mv | AT feiren pseudoprogressionwithosimertinibafterdefinitivechemoradiationinunresectableepidermalgrowthfactorreceptormutationpositiveofstageiiinonsmallcelllungcanceracasereport AT yaowang pseudoprogressionwithosimertinibafterdefinitivechemoradiationinunresectableepidermalgrowthfactorreceptormutationpositiveofstageiiinonsmallcelllungcanceracasereport AT yongshenggao pseudoprogressionwithosimertinibafterdefinitivechemoradiationinunresectableepidermalgrowthfactorreceptormutationpositiveofstageiiinonsmallcelllungcanceracasereport AT xiangjiaomeng pseudoprogressionwithosimertinibafterdefinitivechemoradiationinunresectableepidermalgrowthfactorreceptormutationpositiveofstageiiinonsmallcelllungcanceracasereport AT xiangjiaomeng pseudoprogressionwithosimertinibafterdefinitivechemoradiationinunresectableepidermalgrowthfactorreceptormutationpositiveofstageiiinonsmallcelllungcanceracasereport |