Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats

The downregulation of uncoupling protein-2 (UCP2) is associated with increased brain and kidney injury in stroke-prone spontaneously hypertensive rats (SHRSP) fed with a Japanese style hypersodic diet (JD). Systemic overexpression of UCP2 reduces organ damage in JD-fed SHRSP. We examined the effect...

Full description

Bibliographic Details
Main Authors: Carla L. Busceti, Maria Cotugno, Franca Bianchi, Maurizio Forte, Rosita Stanzione, Simona Marchitti, Giuseppe Battaglia, Ferdinando Nicoletti, Francesco Fornai, Speranza Rubattu
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
UCP2
mitochondria
brain
stroke
renal damage
stroke-prone spontaneously hypertensive rat
Online Access:https://www.mdpi.com/1422-0067/21/12/4289

Internet

https://www.mdpi.com/1422-0067/21/12/4289

Similar Items