Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

INTRODUCTION: Secreted Protein, Acidic and Rich in Cysteine (SPARC) is a matricellular protein involved in many biological processes and found over-expressed in cirrhotic livers. By mean of a genetic approach we herein provide evidence from different in vivo liver disease models suggesting a profibr...

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Main Authors: Catalina Atorrasagasti, Estanislao Peixoto, Jorge B Aquino, Néstor Kippes, Mariana Malvicini, Laura Alaniz, Mariana Garcia, Flavia Piccioni, Esteban J Fiore, Juan Bayo, Ramón Bataller, Elizabeth Guruceaga, Fernando Corrales, Osvaldo Podhajcer, Guillermo Mazzolini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3569438?pdf=render

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