Genetic Landscape of Chronic Myeloid Leukemia and a Novel Targeted Drug for Overcoming Resistance

Genetic Landscape of Chronic Myeloid Leukemia and a Novel Targeted Drug for Overcoming Resistance

Tyrosine kinase inhibitors (TKIs) exemplify the success of molecular targeted therapy for chronic myeloid leukemia (CML). However, some patients do not respond to TKI therapy. Mutations in the kinase domain of <i>BCR::ABL1</i> are the most extensively studied mechanism of TKI resistance...

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Bibliographic Details
Main Authors:	Ryo Yoshimaru, Yosuke Minami
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	International Journal of Molecular Sciences
Subjects:	chronic myeloid leukemia genome profiling asciminib
Online Access:	https://www.mdpi.com/1422-0067/24/18/13806

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