The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells

The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells

Colorectal cancer is a major global health problem resulting in over 600,000 deaths world-wide every year with the majority of these due to metastatic disease. Wnt signalling, and more specifically β-catenin-related transcription, has been shown to drive both tumorigenesis and the metastatic process...

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Bibliographic Details
Main Authors: David Qualtrough, Phil Rees, Beverley Speight, Ann C. Williams, Christos Paraskeva
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Cancers
Subjects:
colorectal cancer
Wnt signalling
hedgehog signalling
E-cadherin
cyclopamine
β-catenin/Tcf
EMT
invasion
Online Access:http://www.mdpi.com/2072-6694/7/3/0867

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