The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients
Objectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population. Materials and Methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detecti...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Tzu-Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=152;epage=157;aulast=Obayes |
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| author | Falah Hasan Obayes AL-Khikani Zaytoon Abdulridha Alkhafaji |
| author_facet | Falah Hasan Obayes AL-Khikani Zaytoon Abdulridha Alkhafaji |
| author_sort | Falah Hasan Obayes AL-Khikani |
| collection | DOAJ |
| description | Objectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population. Materials and Methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detection of IL12A rs568408 gene polymorphism in a case–control study of 125 severe COVID-19 cases and 60 controls. Patients were admitted to either Marjan medical city or Al-Sadeq hospital's COVID-19 wards between January and June 2022 in Iraq. The diagnosis of COVID-19 in each patient was confirmed by severe acute respiratory coronavirus 2-positive reverse transcription-PCR. Results: The distribution of both genotyping and allele frequencies of IL-12A rs568408 revealed significant differences between patients and control groups (P = 0.006 and P = 0.001, respectively). The IL12A rs568408 AA and AG variant genotypes were associated with a significantly increased risk of COVID-19 (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 1.13–23.82; P = 0.034) and (OR = 2.39, 95% CI = 1.16–4.94, P = 0.018), respectively, compared with the wild-type GG homozygote. Conclusion: These findings indicate that IL12A rs568408 GA/AA variant may contribute to the risk of COVID-19. This study is the first report about the association of IL12A rs568408 with COVID-19. |
| first_indexed | 2024-03-12T22:34:08Z |
| format | Article |
| id | doaj.art-02cab37da8bc4f65a0e020371935c991 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-03-12T22:34:08Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-02cab37da8bc4f65a0e020371935c9912023-07-21T13:08:21ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562023-01-0135215215710.4103/tcmj.tcmj_223_22The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patientsFalah Hasan Obayes AL-KhikaniZaytoon Abdulridha AlkhafajiObjectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population. Materials and Methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detection of IL12A rs568408 gene polymorphism in a case–control study of 125 severe COVID-19 cases and 60 controls. Patients were admitted to either Marjan medical city or Al-Sadeq hospital's COVID-19 wards between January and June 2022 in Iraq. The diagnosis of COVID-19 in each patient was confirmed by severe acute respiratory coronavirus 2-positive reverse transcription-PCR. Results: The distribution of both genotyping and allele frequencies of IL-12A rs568408 revealed significant differences between patients and control groups (P = 0.006 and P = 0.001, respectively). The IL12A rs568408 AA and AG variant genotypes were associated with a significantly increased risk of COVID-19 (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 1.13–23.82; P = 0.034) and (OR = 2.39, 95% CI = 1.16–4.94, P = 0.018), respectively, compared with the wild-type GG homozygote. Conclusion: These findings indicate that IL12A rs568408 GA/AA variant may contribute to the risk of COVID-19. This study is the first report about the association of IL12A rs568408 with COVID-19.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=152;epage=157;aulast=Obayescovid-19il12apolymorphismrs568408 |
| spellingShingle | Falah Hasan Obayes AL-Khikani Zaytoon Abdulridha Alkhafaji The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients Tzu-Chi Medical Journal covid-19 il12a polymorphism rs568408 |
| title | The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients |
| title_full | The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients |
| title_fullStr | The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients |
| title_full_unstemmed | The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients |
| title_short | The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients |
| title_sort | rs568408 variant in the il 12a gene is associated with risk for covid 19 in iraqi patients |
| topic | covid-19 il12a polymorphism rs568408 |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=2;spage=152;epage=157;aulast=Obayes |
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