Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment
Vascular myelopathy is a rare severe disease caused by a broad spectrum of causes, among which pathology of the aorta and its branches, aortic surgery, spinal diseases, and spinal trauma occupy the main place. The processes of neuroinflammation and glutamate neurotoxicity play a leading role in the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-04-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/824 |
| _version_ | 1797876400167845888 |
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| author | G. V. Ponomarev A. A. Skoromets V. S. Krasnov O. V. Rodionova D. D. Glistenkova N. F. Porkhun S. A. Dambinova |
| author_facet | G. V. Ponomarev A. A. Skoromets V. S. Krasnov O. V. Rodionova D. D. Glistenkova N. F. Porkhun S. A. Dambinova |
| author_sort | G. V. Ponomarev |
| collection | DOAJ |
| description | Vascular myelopathy is a rare severe disease caused by a broad spectrum of causes, among which pathology of the aorta and its branches, aortic surgery, spinal diseases, and spinal trauma occupy the main place. The processes of neuroinflammation and glutamate neurotoxicity play a leading role in the pathogenesis of myeloischemia. The clinical picture of the disease is nonspecific and depends on the location and volume of an ischemic focus. Magnetic resonance imaging is a gold standard for diagnosis. However, this method remains insensitive in the acute period and fails to detect spinal cord ischemia at preclinical stages. The investigation and introduction of specific biochemical markers (glutamate receptors and their antibodies) for neurotoxicity, which can identify ischemia in the advanced stage and predetermine its development, are promising. The treatment of vascular myelopathy has not currently been standardized and it is mainly pathogenetic and symptomatic. |
| first_indexed | 2024-04-10T02:01:32Z |
| format | Article |
| id | doaj.art-02cbdc3799b24c1c9328122470375561 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:01:32Z |
| publishDate | 2018-04-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-02cbdc3799b24c1c93281224703755612023-03-13T08:42:17ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422018-04-01101121610.14412/2074-2711-2018-1-12-16703Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatmentG. V. Ponomarev0A. A. Skoromets1V. S. Krasnov2O. V. Rodionova3D. D. Glistenkova4N. F. Porkhun5S. A. Dambinova6Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaAcademician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaVascular myelopathy is a rare severe disease caused by a broad spectrum of causes, among which pathology of the aorta and its branches, aortic surgery, spinal diseases, and spinal trauma occupy the main place. The processes of neuroinflammation and glutamate neurotoxicity play a leading role in the pathogenesis of myeloischemia. The clinical picture of the disease is nonspecific and depends on the location and volume of an ischemic focus. Magnetic resonance imaging is a gold standard for diagnosis. However, this method remains insensitive in the acute period and fails to detect spinal cord ischemia at preclinical stages. The investigation and introduction of specific biochemical markers (glutamate receptors and their antibodies) for neurotoxicity, which can identify ischemia in the advanced stage and predetermine its development, are promising. The treatment of vascular myelopathy has not currently been standardized and it is mainly pathogenetic and symptomatic.https://nnp.ima-press.net/nnp/article/view/824spinal cordischemiacausesmechanismsclinical picturediagnosistreatmentbiomarkersglutamate |
| spellingShingle | G. V. Ponomarev A. A. Skoromets V. S. Krasnov O. V. Rodionova D. D. Glistenkova N. F. Porkhun S. A. Dambinova Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment Неврология, нейропсихиатрия, психосоматика spinal cord ischemia causes mechanisms clinical picture diagnosis treatment biomarkers glutamate |
| title | Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment |
| title_full | Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment |
| title_fullStr | Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment |
| title_full_unstemmed | Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment |
| title_short | Vascular myelopathy: causes and mechanisms, possibilities of diagnosis and treatment |
| title_sort | vascular myelopathy causes and mechanisms possibilities of diagnosis and treatment |
| topic | spinal cord ischemia causes mechanisms clinical picture diagnosis treatment biomarkers glutamate |
| url | https://nnp.ima-press.net/nnp/article/view/824 |
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