Evaluation of Vaccine Immunogenicity—Correlates to Real-World Protection: Influenza

Recent events highlighted that, despite decades of studying vaccine immunogenicity and efforts toward finding correlates of protection, evaluating real-world vaccine efficacy as well as establishing meaningful licensing criteria still represents a significant challenge. In this paper, we review all...

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Bibliographic Details
Main Authors: Csaba Laszlofy, Gyorgy Fazekas, Zoltan Barath, Zoltan Vajo
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/16/3/441
Description
Summary:Recent events highlighted that, despite decades of studying vaccine immunogenicity and efforts toward finding correlates of protection, evaluating real-world vaccine efficacy as well as establishing meaningful licensing criteria still represents a significant challenge. In this paper, we review all aspects of influenza vaccine immunogenicity, including animal and human challenge studies, humoral and cellular immunity parameters, and their potential correlation with real-life protection from disease.
ISSN:1999-4915