Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province
ObjectiveTo determine the characteristics， viral load and immunological status of HIV-infected persons and their spouses who became HIV-positive， and the reasons for HIV seroconversion in 55 HIV discordant couples in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture）， Yunan Province.Met...
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| Format: | Article |
| Language: | zho |
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Shanghai Preventive Medicine Association
2023-12-01
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| Series: | Shanghai yufang yixue |
| Subjects: | |
| Online Access: | http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22930 |
| _version_ | 1797198689229340672 |
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| author | LI Yanling HE Shuxian CAO Yanfen XIANG Lifen GONG Yurong YANG Yuecheng YE Runhua TANG Renhai DING Yingying HE Na DUAN Song |
| author_facet | LI Yanling HE Shuxian CAO Yanfen XIANG Lifen GONG Yurong YANG Yuecheng YE Runhua TANG Renhai DING Yingying HE Na DUAN Song |
| author_sort | LI Yanling |
| collection | DOAJ |
| description | ObjectiveTo determine the characteristics， viral load and immunological status of HIV-infected persons and their spouses who became HIV-positive， and the reasons for HIV seroconversion in 55 HIV discordant couples in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture）， Yunan Province.MethodsData on the 55 couples meeting the criteria of having a previously positive spouse were retrieved from the AIDS Integrated Prevention and Control Data Information System of the China Disease Control and Prevention Information System during 2015-2021. General socio-demographic information， age at diagnosis， exposure history， CD4+T lymphocyte count， and antiviral treatment were collected. Descriptive analysis and chi-square test were used to compare the distribution of pre-HIV-positive spouses and their HIV seroconverted spouses.ResultsA total of 55 spouses from HIV discordant couples had HIV seroconversion. Of them， 72.7% （40/55） of pre-HIV-positive spouses were husbands. The most recent CD4+T lymphocyte count in the pre-HIV-positive spouses was （328.31± 246.27） cells·μL-1 at the time of diagnosis of their seroconverted spouses， of which 36.3% （20/55） had a CD4+T lymphocyte count of less than 200 cells·μL-1. Furthermore， of those pre-HIV-positive spouses with low CD4+T lymphocyte count， 45.0% （9/20） had an undetectable viral load， 15.0% （3/20） <400 copies·mL-1， and 25.0%（5/20） ≥400 copies·mL-1. Additionally， 16.4% （9/55） of the pre-HIV-positive spouses did not have a viral load test. The main reasons for HIV seroconversion among HIV-negative spouses in the discordant couples were poor condom use， poor compliance with antiviral therapy， and treatment discontinuation.ConclusionThe follow-up management of HIV discordant couples should be strengthened in Dehong Prefecture， especially the monitoring of viral load levels and immunological status of pre-HIV-positive spouses， to improve their compliance with antiviral therapy and reduce treatment discontinuation， which would effectively prevent and control HIV transmission between spouses. |
| first_indexed | 2024-04-24T07:03:51Z |
| format | Article |
| id | doaj.art-02cd88c2e0e7423e9f44ac432ce743f4 |
| institution | Directory Open Access Journal |
| issn | 1004-9231 |
| language | zho |
| last_indexed | 2024-04-24T07:03:51Z |
| publishDate | 2023-12-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj.art-02cd88c2e0e7423e9f44ac432ce743f42024-04-22T05:13:30ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312023-12-0135121175118010.19428/j.cnki.sjpm.2023.229301004-9231（2023）12-1175-06Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan ProvinceLI Yanling0HE Shuxian1CAO Yanfen2XIANG Lifen3GONG Yurong4YANG Yuecheng5YE Runhua6TANG Renhai7DING Yingying8HE Na9DUAN Song10Department for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaSchool of Public Health， Fudan University，Key Laboratory of Public Health Safety of Ministry of Education， Shanghai 200032， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaSchool of Public Health， Fudan University，Key Laboratory of Public Health Safety of Ministry of Education， Shanghai 200032， ChinaSchool of Public Health， Fudan University，Key Laboratory of Public Health Safety of Ministry of Education， Shanghai 200032， ChinaDepartment for AIDS and STD Prevention and Control， Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention， Mangshi， Yunnan 678400， ChinaObjectiveTo determine the characteristics， viral load and immunological status of HIV-infected persons and their spouses who became HIV-positive， and the reasons for HIV seroconversion in 55 HIV discordant couples in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture）， Yunan Province.MethodsData on the 55 couples meeting the criteria of having a previously positive spouse were retrieved from the AIDS Integrated Prevention and Control Data Information System of the China Disease Control and Prevention Information System during 2015-2021. General socio-demographic information， age at diagnosis， exposure history， CD4+T lymphocyte count， and antiviral treatment were collected. Descriptive analysis and chi-square test were used to compare the distribution of pre-HIV-positive spouses and their HIV seroconverted spouses.ResultsA total of 55 spouses from HIV discordant couples had HIV seroconversion. Of them， 72.7% （40/55） of pre-HIV-positive spouses were husbands. The most recent CD4+T lymphocyte count in the pre-HIV-positive spouses was （328.31± 246.27） cells·μL-1 at the time of diagnosis of their seroconverted spouses， of which 36.3% （20/55） had a CD4+T lymphocyte count of less than 200 cells·μL-1. Furthermore， of those pre-HIV-positive spouses with low CD4+T lymphocyte count， 45.0% （9/20） had an undetectable viral load， 15.0% （3/20） <400 copies·mL-1， and 25.0%（5/20） ≥400 copies·mL-1. Additionally， 16.4% （9/55） of the pre-HIV-positive spouses did not have a viral load test. The main reasons for HIV seroconversion among HIV-negative spouses in the discordant couples were poor condom use， poor compliance with antiviral therapy， and treatment discontinuation.ConclusionThe follow-up management of HIV discordant couples should be strengthened in Dehong Prefecture， especially the monitoring of viral load levels and immunological status of pre-HIV-positive spouses， to improve their compliance with antiviral therapy and reduce treatment discontinuation， which would effectively prevent and control HIV transmission between spouses.http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22930aidshiv discordant coupleseroconversiontransmission between spouseviral loadimmunological status |
| spellingShingle | LI Yanling HE Shuxian CAO Yanfen XIANG Lifen GONG Yurong YANG Yuecheng YE Runhua TANG Renhai DING Yingying HE Na DUAN Song Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province Shanghai yufang yixue aids hiv discordant couple seroconversion transmission between spouse viral load immunological status |
| title | Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province |
| title_full | Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province |
| title_fullStr | Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province |
| title_full_unstemmed | Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province |
| title_short | Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefecture， Yunnan Province |
| title_sort | characteristics of hiv infected persons and their spouses who became hiv positive in hiv discordant couples in dehong prefecture yunnan province |
| topic | aids hiv discordant couple seroconversion transmission between spouse viral load immunological status |
| url | http://www.sjpm.org.cn/cn/article/doi/10.19428/j.cnki.sjpm.2023.22930 |
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