TPH1 and 5-HT<sub>7</sub> Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma

TPH1 and 5-HT<sub>7</sub> Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma

In the present study, we investigated the regulatory mechanisms underlying overexpression of EZH2, tryptophan hydroxylase 1 (TPH1), and 5-HT<sub>7</sub>, in relation to gemcitabine resistance and CSC survival in PDAC cells. In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZ...

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Bibliographic Details
Main Authors: Prakash Chaudhary, Diwakar Guragain, Jae-Hoon Chang, Jung-Ae Kim
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
gemcitabine-resistance
cancer stem cells
Enhancer of zeste homolog 2
tryptophan hydroxylase 1
5-HT<sub>7</sub>
Online Access:https://www.mdpi.com/2072-6694/13/21/5305

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