Female Pattern Hair Loss: An Overview with Focus on the Genetics
Pattern hair loss can occur in both men and women, and the underlying molecular mechanisms have been continuously studied in recent years. Male androgenetic alopecia (M-AGA), also termed male pattern hair loss, is the most common type of hair loss in men. M-AGA is considered an androgen-dependent tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/7/1326 |
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| author | Chih-Yi Ho Jeff Yi-Fu Chen Wen-Li Hsu Sebastian Yu Wei-Chiao Chen Szu-Hao Chiu Hui-Ru Yang Sheng-Yao Lin Ching-Ying Wu |
| author_facet | Chih-Yi Ho Jeff Yi-Fu Chen Wen-Li Hsu Sebastian Yu Wei-Chiao Chen Szu-Hao Chiu Hui-Ru Yang Sheng-Yao Lin Ching-Ying Wu |
| author_sort | Chih-Yi Ho |
| collection | DOAJ |
| description | Pattern hair loss can occur in both men and women, and the underlying molecular mechanisms have been continuously studied in recent years. Male androgenetic alopecia (M-AGA), also termed male pattern hair loss, is the most common type of hair loss in men. M-AGA is considered an androgen-dependent trait with a background of genetic predisposition. The interplay between genetic and non-genetic factors leads to the phenotype of follicular miniaturization. Although this similar pattern of phenotypic miniaturization can also be found in female pattern hair loss (FPHL), the corresponding genetic factors in M-AGA do not account for the phenotype in FPHL, indicating that there are different genes contributing to FPHL. Therefore, the role of genetic factors in FPHL is still uncertain. Understanding the genetic mechanism that causes FPHL is crucial for the future development of personalized treatment strategies. This review aims to highlight the differences in the ethnic prevalence and genetic background of FPHL, as well as the current genetic research progress in nutrition, Wnt signaling, and sex hormones related to FPHL. |
| first_indexed | 2024-03-11T01:02:14Z |
| format | Article |
| id | doaj.art-02cf526ff8b543debea8186aa95302dc |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T01:02:14Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-02cf526ff8b543debea8186aa95302dc2023-11-18T19:28:46ZengMDPI AGGenes2073-44252023-06-01147132610.3390/genes14071326Female Pattern Hair Loss: An Overview with Focus on the GeneticsChih-Yi Ho0Jeff Yi-Fu Chen1Wen-Li Hsu2Sebastian Yu3Wei-Chiao Chen4Szu-Hao Chiu5Hui-Ru Yang6Sheng-Yao Lin7Ching-Ying Wu8School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanDepartment of Laboratory Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, TaiwanPattern hair loss can occur in both men and women, and the underlying molecular mechanisms have been continuously studied in recent years. Male androgenetic alopecia (M-AGA), also termed male pattern hair loss, is the most common type of hair loss in men. M-AGA is considered an androgen-dependent trait with a background of genetic predisposition. The interplay between genetic and non-genetic factors leads to the phenotype of follicular miniaturization. Although this similar pattern of phenotypic miniaturization can also be found in female pattern hair loss (FPHL), the corresponding genetic factors in M-AGA do not account for the phenotype in FPHL, indicating that there are different genes contributing to FPHL. Therefore, the role of genetic factors in FPHL is still uncertain. Understanding the genetic mechanism that causes FPHL is crucial for the future development of personalized treatment strategies. This review aims to highlight the differences in the ethnic prevalence and genetic background of FPHL, as well as the current genetic research progress in nutrition, Wnt signaling, and sex hormones related to FPHL.https://www.mdpi.com/2073-4425/14/7/1326female pattern hair lossgenetic factorssingle nucleotide polymorphism (SNP)androgenetic alopeciasex hormonestargeted gene therapy |
| spellingShingle | Chih-Yi Ho Jeff Yi-Fu Chen Wen-Li Hsu Sebastian Yu Wei-Chiao Chen Szu-Hao Chiu Hui-Ru Yang Sheng-Yao Lin Ching-Ying Wu Female Pattern Hair Loss: An Overview with Focus on the Genetics Genes female pattern hair loss genetic factors single nucleotide polymorphism (SNP) androgenetic alopecia sex hormones targeted gene therapy |
| title | Female Pattern Hair Loss: An Overview with Focus on the Genetics |
| title_full | Female Pattern Hair Loss: An Overview with Focus on the Genetics |
| title_fullStr | Female Pattern Hair Loss: An Overview with Focus on the Genetics |
| title_full_unstemmed | Female Pattern Hair Loss: An Overview with Focus on the Genetics |
| title_short | Female Pattern Hair Loss: An Overview with Focus on the Genetics |
| title_sort | female pattern hair loss an overview with focus on the genetics |
| topic | female pattern hair loss genetic factors single nucleotide polymorphism (SNP) androgenetic alopecia sex hormones targeted gene therapy |
| url | https://www.mdpi.com/2073-4425/14/7/1326 |
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