Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose
Western diets high in fat and sucrose are associated with metabolic syndrome (MetS). Although the prevalence of MetS in women is comparable to that in men, metabolic adaptations in females to Western diet have not been reported in preclinical studies. This study investigates the effects of Western d...
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2233 |
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| author | Scott Fuller Yongmei Yu Timothy D. Allerton Tamra Mendoza David M. Ribnicky Z. Elizabeth Floyd |
| author_facet | Scott Fuller Yongmei Yu Timothy D. Allerton Tamra Mendoza David M. Ribnicky Z. Elizabeth Floyd |
| author_sort | Scott Fuller |
| collection | DOAJ |
| description | Western diets high in fat and sucrose are associated with metabolic syndrome (MetS). Although the prevalence of MetS in women is comparable to that in men, metabolic adaptations in females to Western diet have not been reported in preclinical studies. This study investigates the effects of Western diet on risk factors for MetS in female mice. Based on our earlier studies in male mice, we hypothesized that dietary supplementation with extracts of <i>Artemisia dracunculus</i> L. (PMI5011) and <i>Momordica charantia</i> (bitter melon) could affect MetS risk factors in females. Eight-week-old female mice were fed a 10% kcal fat, 17% kcal sucrose diet (LFD); high-fat, high-sucrose diet (HFS; 45% kcal fat, 30% kcal sucrose); or HFS diet with PMI5011 or bitter melon for three months. Body weight and adiposity in all HFS groups were greater than the LFD. Total cholesterol level was elevated with the HFS diets along with LDL cholesterol, but triglycerides and free fatty acids were unchanged from the LFD. Over the three month period, female mice responded to the HFS diet by adaptive increases in fat oxidation energy in muscle and liver. This was coupled with increased fat storage in white and brown adipose tissue depots. These responses were enhanced with botanical supplementation and confer protection from ectopic lipid accumulation associated with MetS in female mice fed an HFS diet. |
| first_indexed | 2024-03-10T18:11:39Z |
| format | Article |
| id | doaj.art-02d03ad3119e4d4796189d9ba316e105 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:11:39Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-02d03ad3119e4d4796189d9ba316e1052023-11-20T08:02:58ZengMDPI AGNutrients2072-66432020-07-01128223310.3390/nu12082233Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and SucroseScott Fuller0Yongmei Yu1Timothy D. Allerton2Tamra Mendoza3David M. Ribnicky4Z. Elizabeth Floyd5Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USADepartment of Plant Biology, Rutgers University, New Brunswick, NJ 08901, USAPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USAWestern diets high in fat and sucrose are associated with metabolic syndrome (MetS). Although the prevalence of MetS in women is comparable to that in men, metabolic adaptations in females to Western diet have not been reported in preclinical studies. This study investigates the effects of Western diet on risk factors for MetS in female mice. Based on our earlier studies in male mice, we hypothesized that dietary supplementation with extracts of <i>Artemisia dracunculus</i> L. (PMI5011) and <i>Momordica charantia</i> (bitter melon) could affect MetS risk factors in females. Eight-week-old female mice were fed a 10% kcal fat, 17% kcal sucrose diet (LFD); high-fat, high-sucrose diet (HFS; 45% kcal fat, 30% kcal sucrose); or HFS diet with PMI5011 or bitter melon for three months. Body weight and adiposity in all HFS groups were greater than the LFD. Total cholesterol level was elevated with the HFS diets along with LDL cholesterol, but triglycerides and free fatty acids were unchanged from the LFD. Over the three month period, female mice responded to the HFS diet by adaptive increases in fat oxidation energy in muscle and liver. This was coupled with increased fat storage in white and brown adipose tissue depots. These responses were enhanced with botanical supplementation and confer protection from ectopic lipid accumulation associated with MetS in female mice fed an HFS diet.https://www.mdpi.com/2072-6643/12/8/2233femalemetabolismbotanicalWestern dietskeletal muscleliver |
| spellingShingle | Scott Fuller Yongmei Yu Timothy D. Allerton Tamra Mendoza David M. Ribnicky Z. Elizabeth Floyd Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose Nutrients female metabolism botanical Western diet skeletal muscle liver |
| title | Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose |
| title_full | Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose |
| title_fullStr | Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose |
| title_full_unstemmed | Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose |
| title_short | Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose |
| title_sort | adaptive fat oxidation is coupled with increased lipid storage in adipose tissue of female mice fed high dietary fat and sucrose |
| topic | female metabolism botanical Western diet skeletal muscle liver |
| url | https://www.mdpi.com/2072-6643/12/8/2233 |
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