Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker?

Background and objectives: Significantly elevated serum ferritin levels are associated with both iron overload and some inflammatory conditions. Hepcidin is a protein that interferes with iron absorption in inflammatory states and acts as an acute-phase reactant. Materials and methods: Here we repo...

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Bibliographic Details
Main Authors: Ana Lopez Aparicio, Alejandro García-Espona-Pancorbo, Marta Clavero-Olmos, Inmaculada Muñoz-Roldán, Alejandro del Castillo-Rueda
Format: Article
Language:English
Published: SMC MEDIA SRL 2015-09-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
Online Access:http://ejcrim.com/index.php/EJCRIM/article/view/240
Description
Summary:Background and objectives: Significantly elevated serum ferritin levels are associated with both iron overload and some inflammatory conditions. Hepcidin is a protein that interferes with iron absorption in inflammatory states and acts as an acute-phase reactant. Materials and methods: Here we report the case a 33-year-old patient who presented with high fever, skin lesions and arthralgia lasting for 2 weeks. His ferritin level was 13,800 µg/l and his hepcidin level was 61 ng/dl. Results: The final diagnosis was adult onset Still's disease. The condition evolved satisfactorily with steroid treatment, but after several weeks the patient presented with an unexpected recurrence. Conclusions: Hepcidin is a good inflammatory marker that could be useful in the differential diagnosis of hyperferritinaemia.
ISSN:2284-2594