Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases
Curcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/1/212 |
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| author | Yu-Wen Kao Sheng-Kai Hsu Jeff Yi-Fu Chen I-Ling Lin Kuo-Jen Chen Po-Yen Lee Hui-Suan Ng Chien-Chih Chiu Kai-Chun Cheng |
| author_facet | Yu-Wen Kao Sheng-Kai Hsu Jeff Yi-Fu Chen I-Ling Lin Kuo-Jen Chen Po-Yen Lee Hui-Suan Ng Chien-Chih Chiu Kai-Chun Cheng |
| author_sort | Yu-Wen Kao |
| collection | DOAJ |
| description | Curcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have become a relatively new research focus over the past few years. Additionally, accumulating evidence suggests that curcumin or curcuminoid metabolites have similar or better biological activity than the precursor of curcumin. Recent studies focus on the protective role of plasma tetrahydrocurcumin (THC), a main metabolite of curcumin, against tumors and chronic inflammatory diseases. Nevertheless, studies of THC in eye diseases have not yet been conducted. Since ophthalmic conditions play a crucial role in worldwide public health, the prevention and treatment of ophthalmic diseases are of great concern. Therefore, the present study investigated the antioxidative, anti-inflammatory, antiangiogenic, and neuroprotective effects of THC on four major ocular diseases: age-related cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). While this study aimed to show curcumin as a promising potential solution for eye conditions and discusses the involved mechanistic pathways, further work is required for the clinical application of curcumin. |
| first_indexed | 2024-03-10T13:43:11Z |
| format | Article |
| id | doaj.art-02d1dfbbf7e34beda622821d142cbdd4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:43:11Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-02d1dfbbf7e34beda622821d142cbdd42023-11-21T02:48:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122121210.3390/ijms22010212Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye DiseasesYu-Wen Kao0Sheng-Kai Hsu1Jeff Yi-Fu Chen2I-Ling Lin3Kuo-Jen Chen4Po-Yen Lee5Hui-Suan Ng6Chien-Chih Chiu7Kai-Chun Cheng8Department of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, TaiwanDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanFaculty of Applied Sciences, UCSI University, UCSI Heights, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, TaiwanCurcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have become a relatively new research focus over the past few years. Additionally, accumulating evidence suggests that curcumin or curcuminoid metabolites have similar or better biological activity than the precursor of curcumin. Recent studies focus on the protective role of plasma tetrahydrocurcumin (THC), a main metabolite of curcumin, against tumors and chronic inflammatory diseases. Nevertheless, studies of THC in eye diseases have not yet been conducted. Since ophthalmic conditions play a crucial role in worldwide public health, the prevention and treatment of ophthalmic diseases are of great concern. Therefore, the present study investigated the antioxidative, anti-inflammatory, antiangiogenic, and neuroprotective effects of THC on four major ocular diseases: age-related cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). While this study aimed to show curcumin as a promising potential solution for eye conditions and discusses the involved mechanistic pathways, further work is required for the clinical application of curcumin.https://www.mdpi.com/1422-0067/22/1/212curcuminCOXSIRT1tetrahydrocurcumin (THC)ophthalmic diseasesVEGF |
| spellingShingle | Yu-Wen Kao Sheng-Kai Hsu Jeff Yi-Fu Chen I-Ling Lin Kuo-Jen Chen Po-Yen Lee Hui-Suan Ng Chien-Chih Chiu Kai-Chun Cheng Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases International Journal of Molecular Sciences curcumin COX SIRT1 tetrahydrocurcumin (THC) ophthalmic diseases VEGF |
| title | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases |
| title_full | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases |
| title_fullStr | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases |
| title_full_unstemmed | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases |
| title_short | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases |
| title_sort | curcumin metabolite tetrahydrocurcumin in the treatment of eye diseases |
| topic | curcumin COX SIRT1 tetrahydrocurcumin (THC) ophthalmic diseases VEGF |
| url | https://www.mdpi.com/1422-0067/22/1/212 |
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