Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses
Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses into different effector subtypes. Polarized T ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01529/full |
| _version_ | 1818872952040456192 |
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| author | Demo Yemane Tesfaye Demo Yemane Tesfaye Arnar Gudjonsson Arnar Gudjonsson Bjarne Bogen Bjarne Bogen Bjarne Bogen Even Fossum Even Fossum |
| author_facet | Demo Yemane Tesfaye Demo Yemane Tesfaye Arnar Gudjonsson Arnar Gudjonsson Bjarne Bogen Bjarne Bogen Bjarne Bogen Even Fossum Even Fossum |
| author_sort | Demo Yemane Tesfaye |
| collection | DOAJ |
| description | Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses into different effector subtypes. Polarized T cells in turn have a crucial role in antibody class switching and affinity maturation, and consequently the quality of the resulting humoral immunity. Targeting vaccines to DCs thus provides a great deal of opportunities for influencing the humoral immune responses, by fine-tuning the T cell response as well as regulating antigen availability for B cells. In this review we aim to outline how different DC targeted vaccination strategies can be utilized to induce a desired humoral immune response. A range of factors, including route of vaccine administration, use of adjuvants, choice of DC subset and surface receptor to target have been reported to influence the resulting immune response and will be reviewed herein. Finally, we will discuss opportunities for designing improved vaccines and challenges with translating this knowledge into clinical or veterinary medicine. |
| first_indexed | 2024-12-19T12:46:59Z |
| format | Article |
| id | doaj.art-02d28d8984f34cd3bdae9212b4b79c5e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T12:46:59Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-02d28d8984f34cd3bdae9212b4b79c5e2022-12-21T20:20:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01529462925Targeting Conventional Dendritic Cells to Fine-Tune Antibody ResponsesDemo Yemane Tesfaye0Demo Yemane Tesfaye1Arnar Gudjonsson2Arnar Gudjonsson3Bjarne Bogen4Bjarne Bogen5Bjarne Bogen6Even Fossum7Even Fossum8K. G. Jebsen Center for Research on Influenza Vaccines, Oslo University Hospital, University of Oslo, Oslo, NorwayDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, NorwayK. G. Jebsen Center for Research on Influenza Vaccines, Oslo University Hospital, University of Oslo, Oslo, NorwayInstitute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, NorwayK. G. Jebsen Center for Research on Influenza Vaccines, Oslo University Hospital, University of Oslo, Oslo, NorwayDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, NorwayK. G. Jebsen Center for Research on Influenza Vaccines, Oslo University Hospital, University of Oslo, Oslo, NorwayDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, NorwayDendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses into different effector subtypes. Polarized T cells in turn have a crucial role in antibody class switching and affinity maturation, and consequently the quality of the resulting humoral immunity. Targeting vaccines to DCs thus provides a great deal of opportunities for influencing the humoral immune responses, by fine-tuning the T cell response as well as regulating antigen availability for B cells. In this review we aim to outline how different DC targeted vaccination strategies can be utilized to induce a desired humoral immune response. A range of factors, including route of vaccine administration, use of adjuvants, choice of DC subset and surface receptor to target have been reported to influence the resulting immune response and will be reviewed herein. Finally, we will discuss opportunities for designing improved vaccines and challenges with translating this knowledge into clinical or veterinary medicine.https://www.frontiersin.org/article/10.3389/fimmu.2019.01529/fulldendritic cell (DC)DC subtypesvaccinationtargetingantibodyTh1 & Th2 |
| spellingShingle | Demo Yemane Tesfaye Demo Yemane Tesfaye Arnar Gudjonsson Arnar Gudjonsson Bjarne Bogen Bjarne Bogen Bjarne Bogen Even Fossum Even Fossum Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses Frontiers in Immunology dendritic cell (DC) DC subtypes vaccination targeting antibody Th1 & Th2 |
| title | Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses |
| title_full | Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses |
| title_fullStr | Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses |
| title_full_unstemmed | Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses |
| title_short | Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses |
| title_sort | targeting conventional dendritic cells to fine tune antibody responses |
| topic | dendritic cell (DC) DC subtypes vaccination targeting antibody Th1 & Th2 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01529/full |
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