Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics
Postoperative complications in cardiovascular surgery remain an important unresolved problem, in particular in patients with aortic aneurysm. The role of the altered microbiota in such patients is of great interest. The aim of this pilot study was to determine whether the development of postoperativ...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1335 |
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| author | Natalia Beloborodova Alisa Pautova Marina Grekova Mikhail Yadgarov Oksana Grin Alexander Eremenko Maxim Babaev |
| author_facet | Natalia Beloborodova Alisa Pautova Marina Grekova Mikhail Yadgarov Oksana Grin Alexander Eremenko Maxim Babaev |
| author_sort | Natalia Beloborodova |
| collection | DOAJ |
| description | Postoperative complications in cardiovascular surgery remain an important unresolved problem, in particular in patients with aortic aneurysm. The role of the altered microbiota in such patients is of great interest. The aim of this pilot study was to determine whether the development of postoperative complications in patients with aortic aneurysm is related with initial or acquired disorders of microbiota metabolism by monitoring the level of some aromatic microbial metabolites (AMMs) circulating in the blood before the surgery and in the early postoperative period. The study comprised patients with aortic aneurysm (<i>n</i> = 79), including patients without complications (<i>n</i> = 36) and patients with all types of complications (<i>n</i> = 43). The serum samples from the patients were collected before and 6 h after the end of the surgery. The most significant results were obtained for the sum of three sepsis-associated AMMs. This level was higher before the surgery in comparison with that of healthy volunteers (<i>n</i> = 48), <i>p</i> < 0.001, and it was also higher in the early postoperative period in patients with all types of complications compared to those without complications, <i>p</i> = 0.001; the area under the ROC curve, the cut-off value, and the odds ratio were 0.7; 2.9 µmol/L, and 5.5, respectively. Impaired microbiota metabolism is important in the development of complications after complex reconstructive aortic surgery, which is the basis for the search for a new prevention strategy. |
| first_indexed | 2024-03-11T03:54:21Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:54:21Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-02d29d29324d4b95bdd0c902623e60562023-11-18T00:35:32ZengMDPI AGBiomedicines2227-90592023-04-01115133510.3390/biomedicines11051335Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic ProstheticsNatalia Beloborodova0Alisa Pautova1Marina Grekova2Mikhail Yadgarov3Oksana Grin4Alexander Eremenko5Maxim Babaev6Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25-2 Petrovka Str., 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25-2 Petrovka Str., 107031 Moscow, RussiaPetrovsky Russian Research Center of Surgery, 2 Abrikosovsky Pereulok, 119991 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25-2 Petrovka Str., 107031 Moscow, RussiaPetrovsky Russian Research Center of Surgery, 2 Abrikosovsky Pereulok, 119991 Moscow, RussiaPetrovsky Russian Research Center of Surgery, 2 Abrikosovsky Pereulok, 119991 Moscow, RussiaPetrovsky Russian Research Center of Surgery, 2 Abrikosovsky Pereulok, 119991 Moscow, RussiaPostoperative complications in cardiovascular surgery remain an important unresolved problem, in particular in patients with aortic aneurysm. The role of the altered microbiota in such patients is of great interest. The aim of this pilot study was to determine whether the development of postoperative complications in patients with aortic aneurysm is related with initial or acquired disorders of microbiota metabolism by monitoring the level of some aromatic microbial metabolites (AMMs) circulating in the blood before the surgery and in the early postoperative period. The study comprised patients with aortic aneurysm (<i>n</i> = 79), including patients without complications (<i>n</i> = 36) and patients with all types of complications (<i>n</i> = 43). The serum samples from the patients were collected before and 6 h after the end of the surgery. The most significant results were obtained for the sum of three sepsis-associated AMMs. This level was higher before the surgery in comparison with that of healthy volunteers (<i>n</i> = 48), <i>p</i> < 0.001, and it was also higher in the early postoperative period in patients with all types of complications compared to those without complications, <i>p</i> = 0.001; the area under the ROC curve, the cut-off value, and the odds ratio were 0.7; 2.9 µmol/L, and 5.5, respectively. Impaired microbiota metabolism is important in the development of complications after complex reconstructive aortic surgery, which is the basis for the search for a new prevention strategy.https://www.mdpi.com/2227-9059/11/5/1335cardiovascular surgery patientsaortic aneurismaortic dissectionaromatic microbial metabolitestyrosine metabolites4-hydroxyphenyllactic acid |
| spellingShingle | Natalia Beloborodova Alisa Pautova Marina Grekova Mikhail Yadgarov Oksana Grin Alexander Eremenko Maxim Babaev Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics Biomedicines cardiovascular surgery patients aortic aneurism aortic dissection aromatic microbial metabolites tyrosine metabolites 4-hydroxyphenyllactic acid |
| title | Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics |
| title_full | Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics |
| title_fullStr | Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics |
| title_full_unstemmed | Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics |
| title_short | Microbiota Metabolism Failure as a Risk Factor for Postoperative Complications after Aortic Prosthetics |
| title_sort | microbiota metabolism failure as a risk factor for postoperative complications after aortic prosthetics |
| topic | cardiovascular surgery patients aortic aneurism aortic dissection aromatic microbial metabolites tyrosine metabolites 4-hydroxyphenyllactic acid |
| url | https://www.mdpi.com/2227-9059/11/5/1335 |
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