Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations
The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1376151/full |
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| author | Meiqi Han Meiqi Han Yu Wang Yu Wang Luyi Jing Luyi Jing Gucheng Yang Gucheng Yang Yaoyao Liu Yaoyao Liu Fan Mo Fan Mo Zhaojie Xu Zhaojie Xu Jinping Luo Jinping Luo Qianli Jia Qianli Jia Yuxin Zhu Yuxin Zhu Hanwen Cao Hanwen Cao Xinxia Cai Xinxia Cai Juntao Liu Juntao Liu |
| author_facet | Meiqi Han Meiqi Han Yu Wang Yu Wang Luyi Jing Luyi Jing Gucheng Yang Gucheng Yang Yaoyao Liu Yaoyao Liu Fan Mo Fan Mo Zhaojie Xu Zhaojie Xu Jinping Luo Jinping Luo Qianli Jia Qianli Jia Yuxin Zhu Yuxin Zhu Hanwen Cao Hanwen Cao Xinxia Cai Xinxia Cai Juntao Liu Juntao Liu |
| author_sort | Meiqi Han |
| collection | DOAJ |
| description | The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10.5 ± 1.1 kΩ), and maintained exceptional stability, with impedance levels remaining consistently low (23 kΩ) even 14 days post-implantation. As seizure intensity escalated, we observed a corresponding increase in neuronal firing rates and local field potential power, with a notable shift towards higher frequency peaks and augmented inter-channel correlation. Significantly, during the grand mal seizures, theta and alpha bands became the dominant frequencies in the local field potential. Compared to the normal group, the spike firing rates on day 3 and 7 post-modeling were significantly higher, accompanied by a decreased firing interval. Power in both delta and theta bands exhibited an increasing trend, correlating with the duration of epilepsy. These findings offer valuable insights into the dynamic processes of striatal neural activity during the initial and latent phases of temporal lobe epilepsy and contribute to our understanding of the neural mechanisms underpinning epilepsy. |
| first_indexed | 2024-04-24T14:06:07Z |
| format | Article |
| id | doaj.art-02d35b6d72404c4cb48a2d0509ec6b4a |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-24T14:06:07Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-02d35b6d72404c4cb48a2d0509ec6b4a2024-04-03T10:23:55ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-03-011210.3389/fbioe.2024.13761511376151Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterationsMeiqi Han0Meiqi Han1Yu Wang2Yu Wang3Luyi Jing4Luyi Jing5Gucheng Yang6Gucheng Yang7Yaoyao Liu8Yaoyao Liu9Fan Mo10Fan Mo11Zhaojie Xu12Zhaojie Xu13Jinping Luo14Jinping Luo15Qianli Jia16Qianli Jia17Yuxin Zhu18Yuxin Zhu19Hanwen Cao20Hanwen Cao21Xinxia Cai22Xinxia Cai23Juntao Liu24Juntao Liu25State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, ChinaSchool of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, ChinaThe striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10.5 ± 1.1 kΩ), and maintained exceptional stability, with impedance levels remaining consistently low (23 kΩ) even 14 days post-implantation. As seizure intensity escalated, we observed a corresponding increase in neuronal firing rates and local field potential power, with a notable shift towards higher frequency peaks and augmented inter-channel correlation. Significantly, during the grand mal seizures, theta and alpha bands became the dominant frequencies in the local field potential. Compared to the normal group, the spike firing rates on day 3 and 7 post-modeling were significantly higher, accompanied by a decreased firing interval. Power in both delta and theta bands exhibited an increasing trend, correlating with the duration of epilepsy. These findings offer valuable insights into the dynamic processes of striatal neural activity during the initial and latent phases of temporal lobe epilepsy and contribute to our understanding of the neural mechanisms underpinning epilepsy.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1376151/fullmicroelectrode arraystemporal lobe epilepsystriatumgraphene oxidePEDOT:PSS |
| spellingShingle | Meiqi Han Meiqi Han Yu Wang Yu Wang Luyi Jing Luyi Jing Gucheng Yang Gucheng Yang Yaoyao Liu Yaoyao Liu Fan Mo Fan Mo Zhaojie Xu Zhaojie Xu Jinping Luo Jinping Luo Qianli Jia Qianli Jia Yuxin Zhu Yuxin Zhu Hanwen Cao Hanwen Cao Xinxia Cai Xinxia Cai Juntao Liu Juntao Liu Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations Frontiers in Bioengineering and Biotechnology microelectrode arrays temporal lobe epilepsy striatum graphene oxide PEDOT:PSS |
| title | Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations |
| title_full | Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations |
| title_fullStr | Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations |
| title_full_unstemmed | Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations |
| title_short | Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations |
| title_sort | utilizing go pedot pss ptnps enhanced high stability microelectrode arrays for investigating epilepsy induced striatal electrophysiology alterations |
| topic | microelectrode arrays temporal lobe epilepsy striatum graphene oxide PEDOT:PSS |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1376151/full |
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