Current Research of the Roles of IL-35 in Tumor Progression
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr vi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-04-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.04.09 |
| _version_ | 1831657094669926400 |
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| author | Chongbiao HUANG Ye TIAN Yan CUI Jie XU Liang XIN Xueling YANG Daliang QI |
| author_facet | Chongbiao HUANG Ye TIAN Yan CUI Jie XU Liang XIN Xueling YANG Daliang QI |
| author_sort | Chongbiao HUANG |
| collection | DOAJ |
| description | Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression. |
| first_indexed | 2024-12-19T17:20:38Z |
| format | Article |
| id | doaj.art-02d4343c97d947b6a4d13fae756d0d3b |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-19T17:20:38Z |
| publishDate | 2016-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-02d4343c97d947b6a4d13fae756d0d3b2022-12-21T20:12:41ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-04-0119423023510.3779/j.issn.1009-3419.2016.04.09Current Research of the Roles of IL-35 in Tumor ProgressionChongbiao HUANG0Ye TIAN1Yan CUI2Jie XU3Liang XIN4Xueling YANG5Daliang QI6Department of Senior WardDepartment of Senior WardDepartment of Senior WardDepartment of Senior WardDepartment of Senior WardDepartment of Interventional Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Senior WardInterleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.04.09InterleukinInterleukin-35TumorTumor immunology |
| spellingShingle | Chongbiao HUANG Ye TIAN Yan CUI Jie XU Liang XIN Xueling YANG Daliang QI Current Research of the Roles of IL-35 in Tumor Progression Chinese Journal of Lung Cancer Interleukin Interleukin-35 Tumor Tumor immunology |
| title | Current Research of the Roles of IL-35 in Tumor Progression |
| title_full | Current Research of the Roles of IL-35 in Tumor Progression |
| title_fullStr | Current Research of the Roles of IL-35 in Tumor Progression |
| title_full_unstemmed | Current Research of the Roles of IL-35 in Tumor Progression |
| title_short | Current Research of the Roles of IL-35 in Tumor Progression |
| title_sort | current research of the roles of il 35 in tumor progression |
| topic | Interleukin Interleukin-35 Tumor Tumor immunology |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.04.09 |
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