Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified.
Coxsackievirus A16 (CVA16) is responsible for nearly 50% of all the confirmed hand, foot, and mouth disease (HFMD) cases in mainland China, sometimes it could also cause severe complications, and even death. To clarify the genetic characteristics and the epidemic patterns of CVA16 in mainland China,...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3858299?pdf=render |
| _version_ | 1818153160729952256 |
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| author | Xiangpeng Chen Xiaojuan Tan Jing Li Yu Jin Liming Gong Mei Hong Yonglin Shi Shuangli Zhu Baomin Zhang Shuang Zhang Yong Zhang Naiying Mao Wenbo Xu |
| author_facet | Xiangpeng Chen Xiaojuan Tan Jing Li Yu Jin Liming Gong Mei Hong Yonglin Shi Shuangli Zhu Baomin Zhang Shuang Zhang Yong Zhang Naiying Mao Wenbo Xu |
| author_sort | Xiangpeng Chen |
| collection | DOAJ |
| description | Coxsackievirus A16 (CVA16) is responsible for nearly 50% of all the confirmed hand, foot, and mouth disease (HFMD) cases in mainland China, sometimes it could also cause severe complications, and even death. To clarify the genetic characteristics and the epidemic patterns of CVA16 in mainland China, comprehensive bioinfomatics analyses were performed by using 35 CVA16 whole genome sequences from 1998 to 2011, 593 complete CVA16 VP1 sequences from 1981 to 2011, and prototype strains of human enterovirus species A (EV-A). Analysis on complete VP1 sequences revealed that subgenotypes B1a and B1b were prevalent strains and have been co-circulating in many Asian countries since 2000, especially in mainland China for at least 13 years. While the prevalence of subgenotype B1c (totally 20 strains) was much limited, only found in Malaysia from 2005 to 2007 and in France in 2010. Genotype B2 only caused epidemic in Japan and Malaysia from 1981 to 2000. Both subgenotypes B1a and B1b were potential recombinant viruses containing sequences from other EV-A donors in the 5'-untranslated region and P2, P3 non-structural protein encoding regions. |
| first_indexed | 2024-12-11T14:06:12Z |
| format | Article |
| id | doaj.art-02d5379fac7e46a4b1f9e59377b96c42 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T14:06:12Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-02d5379fac7e46a4b1f9e59377b96c422022-12-22T01:03:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8286110.1371/journal.pone.0082861Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified.Xiangpeng ChenXiaojuan TanJing LiYu JinLiming GongMei HongYonglin ShiShuangli ZhuBaomin ZhangShuang ZhangYong ZhangNaiying MaoWenbo XuCoxsackievirus A16 (CVA16) is responsible for nearly 50% of all the confirmed hand, foot, and mouth disease (HFMD) cases in mainland China, sometimes it could also cause severe complications, and even death. To clarify the genetic characteristics and the epidemic patterns of CVA16 in mainland China, comprehensive bioinfomatics analyses were performed by using 35 CVA16 whole genome sequences from 1998 to 2011, 593 complete CVA16 VP1 sequences from 1981 to 2011, and prototype strains of human enterovirus species A (EV-A). Analysis on complete VP1 sequences revealed that subgenotypes B1a and B1b were prevalent strains and have been co-circulating in many Asian countries since 2000, especially in mainland China for at least 13 years. While the prevalence of subgenotype B1c (totally 20 strains) was much limited, only found in Malaysia from 2005 to 2007 and in France in 2010. Genotype B2 only caused epidemic in Japan and Malaysia from 1981 to 2000. Both subgenotypes B1a and B1b were potential recombinant viruses containing sequences from other EV-A donors in the 5'-untranslated region and P2, P3 non-structural protein encoding regions.http://europepmc.org/articles/PMC3858299?pdf=render |
| spellingShingle | Xiangpeng Chen Xiaojuan Tan Jing Li Yu Jin Liming Gong Mei Hong Yonglin Shi Shuangli Zhu Baomin Zhang Shuang Zhang Yong Zhang Naiying Mao Wenbo Xu Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. PLoS ONE |
| title | Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. |
| title_full | Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. |
| title_fullStr | Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. |
| title_full_unstemmed | Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. |
| title_short | Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. |
| title_sort | molecular epidemiology of coxsackievirus a16 intratype and prevalent intertype recombination identified |
| url | http://europepmc.org/articles/PMC3858299?pdf=render |
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