Primary alveolar rhabdomyosarcoma of the brain: a case report
Abstract Background Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal subtypes; however, few cases of primary br...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04471-w |
| _version_ | 1827310184235532288 |
|---|---|
| author | Layal Al Mahmasani Marwan Najjar Roula Hourany Abeer Tabbarah Sara Sinno Nathalie Chamseddine Reine Abou Zeidane Ghid Amhaz Bassem Youssef Hazem I. Assi |
| author_facet | Layal Al Mahmasani Marwan Najjar Roula Hourany Abeer Tabbarah Sara Sinno Nathalie Chamseddine Reine Abou Zeidane Ghid Amhaz Bassem Youssef Hazem I. Assi |
| author_sort | Layal Al Mahmasani |
| collection | DOAJ |
| description | Abstract Background Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal subtypes; however, few cases of primary brain rhabdomyosarcoma in adults have been reported in the literature. Case presentation We report the case of a 26-year-old White male patient who was found to have primary brain alveolar rhabdomyosarcoma after developing headaches for several months. A brain MRI revealed a mixed cystic and solid tumor along the vermis of the cerebellum. The patient underwent a gross total surgical resection, which confirmed the diagnosis of alveolar rhabdomyosarcoma. Further staging workup for another primary focus or disseminated disease yielded negative results, confirming the diagnosis of primary alveolar rhabdomyosarcoma of the brain. Conclusion The standard of care for managing this rare type of brain tumor involves surgery with adjuvant chemoradiotherapy. Further studies should be conducted for a better diagnostic and therapeutic understanding. |
| first_indexed | 2024-04-24T19:55:35Z |
| format | Article |
| id | doaj.art-02d5f5b6dfda44d98c8a13d6afe35197 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-24T19:55:35Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-02d5f5b6dfda44d98c8a13d6afe351972024-03-24T12:21:44ZengBMCJournal of Medical Case Reports1752-19472024-03-011811410.1186/s13256-024-04471-wPrimary alveolar rhabdomyosarcoma of the brain: a case reportLayal Al Mahmasani0Marwan Najjar1Roula Hourany2Abeer Tabbarah3Sara Sinno4Nathalie Chamseddine5Reine Abou Zeidane6Ghid Amhaz7Bassem Youssef8Hazem I. Assi9Division of Haematology-Oncology, Department of Internal Medicine, American University of Beirut Medical CenterDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical CentreDepartment of Diagnostic Radiology, American University of Beirut Medical CentreDepartment of Pathology, American University of Beirut Medical CentreDepartment of Pathology, American University of Beirut Medical CentreDivision of Haematology-Oncology, Department of Internal Medicine, American University of Beirut Medical CenterDivision of Haematology-Oncology, Department of Internal Medicine, American University of Beirut Medical CenterDivision of Haematology-Oncology, Department of Internal Medicine, American University of Beirut Medical CenterDepartment of Radiation Oncology, American University of Beirut Medical CentreDivision of Haematology-Oncology, Department of Internal Medicine, American University of Beirut Medical CenterAbstract Background Primary brain rhabdomyosarcoma is a rare primary brain malignancy with few case reports. The vast majority of cases of primary brain rhabdomyosarcoma occur in pediatric patients, and immunohistochemistry can distinguish it from embryonal subtypes; however, few cases of primary brain rhabdomyosarcoma in adults have been reported in the literature. Case presentation We report the case of a 26-year-old White male patient who was found to have primary brain alveolar rhabdomyosarcoma after developing headaches for several months. A brain MRI revealed a mixed cystic and solid tumor along the vermis of the cerebellum. The patient underwent a gross total surgical resection, which confirmed the diagnosis of alveolar rhabdomyosarcoma. Further staging workup for another primary focus or disseminated disease yielded negative results, confirming the diagnosis of primary alveolar rhabdomyosarcoma of the brain. Conclusion The standard of care for managing this rare type of brain tumor involves surgery with adjuvant chemoradiotherapy. Further studies should be conducted for a better diagnostic and therapeutic understanding.https://doi.org/10.1186/s13256-024-04471-wPrimary alveolar rhabdomyosarcomaIntracranialMultidisciplinary approach |
| spellingShingle | Layal Al Mahmasani Marwan Najjar Roula Hourany Abeer Tabbarah Sara Sinno Nathalie Chamseddine Reine Abou Zeidane Ghid Amhaz Bassem Youssef Hazem I. Assi Primary alveolar rhabdomyosarcoma of the brain: a case report Journal of Medical Case Reports Primary alveolar rhabdomyosarcoma Intracranial Multidisciplinary approach |
| title | Primary alveolar rhabdomyosarcoma of the brain: a case report |
| title_full | Primary alveolar rhabdomyosarcoma of the brain: a case report |
| title_fullStr | Primary alveolar rhabdomyosarcoma of the brain: a case report |
| title_full_unstemmed | Primary alveolar rhabdomyosarcoma of the brain: a case report |
| title_short | Primary alveolar rhabdomyosarcoma of the brain: a case report |
| title_sort | primary alveolar rhabdomyosarcoma of the brain a case report |
| topic | Primary alveolar rhabdomyosarcoma Intracranial Multidisciplinary approach |
| url | https://doi.org/10.1186/s13256-024-04471-w |
| work_keys_str_mv | AT layalalmahmasani primaryalveolarrhabdomyosarcomaofthebrainacasereport AT marwannajjar primaryalveolarrhabdomyosarcomaofthebrainacasereport AT roulahourany primaryalveolarrhabdomyosarcomaofthebrainacasereport AT abeertabbarah primaryalveolarrhabdomyosarcomaofthebrainacasereport AT sarasinno primaryalveolarrhabdomyosarcomaofthebrainacasereport AT nathaliechamseddine primaryalveolarrhabdomyosarcomaofthebrainacasereport AT reineabouzeidane primaryalveolarrhabdomyosarcomaofthebrainacasereport AT ghidamhaz primaryalveolarrhabdomyosarcomaofthebrainacasereport AT bassemyoussef primaryalveolarrhabdomyosarcomaofthebrainacasereport AT hazemiassi primaryalveolarrhabdomyosarcomaofthebrainacasereport |