Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid
Introduction.The article discusses the search for new and highly effective drugs for the prevention and treatment of cerebrovascular disease. Theaimwas to examine the effect of the acyl hydrazone tropane derivative on individual platelet aggregation (PA) sensitivity in in vitro studies. Results....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2020-09-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/684/533 |
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| author | Ruben S. Mirzoian Alla A. Shabalina Tamara S. Gan’shina Il'ya N. Kurdyumov Antonina I. Turilova Leonid M. Kostochka Anton V. Kozlov Vladislav A. Annushkin Anastasia A. Kornilova Marine M. Tanashyan |
| author_facet | Ruben S. Mirzoian Alla A. Shabalina Tamara S. Gan’shina Il'ya N. Kurdyumov Antonina I. Turilova Leonid M. Kostochka Anton V. Kozlov Vladislav A. Annushkin Anastasia A. Kornilova Marine M. Tanashyan |
| author_sort | Ruben S. Mirzoian |
| collection | DOAJ |
| description | Introduction.The article discusses the search for new and highly effective drugs for the prevention and treatment of cerebrovascular disease. Theaimwas to examine the effect of the acyl hydrazone tropane derivative on individual platelet aggregation (PA) sensitivity in in vitro studies.
Results. We present the results of a pilot study on the effect of a new acyl hydrazone tropane derivative acyl hydrazone (2,3,4-trimethoxy-N'-(8-methyl-8-azabicyclo [3.2.1.] octane-3-ylidene) benzohydrazide hydrochloride on PA properties in vitro in healthy volunteers and in patients with chronic cerebrovascular disease.
Conclusion. The studied compound has a pronounced ability to suppress PA when administered intravenously in vivo in two concentrations, equivalent to doses of 10 and 100 mg/kg, and its effect is superior to the comparator acetylsalicylic acid, which is used in clinical practice as an antiplatelet drug. |
| first_indexed | 2024-04-12T14:21:33Z |
| format | Article |
| id | doaj.art-02d62e016934429eb380e6bd2c674809 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-12T14:21:33Z |
| publishDate | 2020-09-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-02d62e016934429eb380e6bd2c6748092022-12-22T03:29:33ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332020-09-01143535910.25692/ACEN.2020.3.7511Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloidRuben S. Mirzoian0Alla A. Shabalina1Tamara S. Gan’shina2Il'ya N. Kurdyumov3Antonina I. Turilova4Leonid M. Kostochka5Anton V. Kozlov6Vladislav A. Annushkin7Anastasia A. Kornilova8Marine M. Tanashyan9Research Zakusov Institute of PharmacologyResearch Center of NeurologyResearch Zakusov Institute of PharmacologyResearch Zakusov Institute of PharmacologyResearch Zakusov Institute of PharmacologyResearch Zakusov Institute of PharmacologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyIntroduction.The article discusses the search for new and highly effective drugs for the prevention and treatment of cerebrovascular disease. Theaimwas to examine the effect of the acyl hydrazone tropane derivative on individual platelet aggregation (PA) sensitivity in in vitro studies. Results. We present the results of a pilot study on the effect of a new acyl hydrazone tropane derivative acyl hydrazone (2,3,4-trimethoxy-N'-(8-methyl-8-azabicyclo [3.2.1.] octane-3-ylidene) benzohydrazide hydrochloride on PA properties in vitro in healthy volunteers and in patients with chronic cerebrovascular disease. Conclusion. The studied compound has a pronounced ability to suppress PA when administered intravenously in vivo in two concentrations, equivalent to doses of 10 and 100 mg/kg, and its effect is superior to the comparator acetylsalicylic acid, which is used in clinical practice as an antiplatelet drug.https://annaly-nevrologii.com/journal/pathID/article/viewFile/684/533cerebrovascular diseasetropane acyl hydrazone derivativeplatelet aggregationacetylsalicylic acid |
| spellingShingle | Ruben S. Mirzoian Alla A. Shabalina Tamara S. Gan’shina Il'ya N. Kurdyumov Antonina I. Turilova Leonid M. Kostochka Anton V. Kozlov Vladislav A. Annushkin Anastasia A. Kornilova Marine M. Tanashyan Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid Анналы клинической и экспериментальной неврологии cerebrovascular disease tropane acyl hydrazone derivative platelet aggregation acetylsalicylic acid |
| title | Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid |
| title_full | Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid |
| title_fullStr | Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid |
| title_full_unstemmed | Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid |
| title_short | Expanding the horizons of antiplatelet therapy. A pilot study of the antiplatelet properties of a new tropane alkaloid |
| title_sort | expanding the horizons of antiplatelet therapy a pilot study of the antiplatelet properties of a new tropane alkaloid |
| topic | cerebrovascular disease tropane acyl hydrazone derivative platelet aggregation acetylsalicylic acid |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/684/533 |
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