Effect of local anesthetics on renal function: An animal study in Iran
Background: Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in sing...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=106;epage=106;aulast=Gheisari |
| _version_ | 1797352136632172544 |
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| author | Rasul Gheisari Masoud Saatchi Firoozeh Estakhri Mehrdad Vossoughi Mohammad Bazaei Zahra Khosravani |
| author_facet | Rasul Gheisari Masoud Saatchi Firoozeh Estakhri Mehrdad Vossoughi Mohammad Bazaei Zahra Khosravani |
| author_sort | Rasul Gheisari |
| collection | DOAJ |
| description | Background: Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in single-kidney rats.
Materials and Methods: The present experimental animal study with two control groups was done in an animal laboratory. Forty-two rats were randomly assigned to seven groups of six rats, including two control groups and five experimental groups. The experimental groups underwent intraperitoneal anesthesia with 2% lidocaine, 2% lidocaine with 1:80,000 epinephrine, 4% articaine, 3% prilocaine with 0.03 IU Felypressin, and 3% mepivacaine, respectively. Unilateral nephrectomy was done. After 24 h, the rats' blood urea nitrogen (BUN), serum creatinine (Cr), and blood specific gravity (BSG) were measured. A standard dose of anesthetics was injected into the peritoneum for 4 days afterward. Then, these indices were measured again 24 h after the last injection. Data were analyzed using IBM SPSS (version 21.0). One-way analysis of variance, Tukey's honestly significant difference post hoc, and paired t-tests were used for statistical analysis. P < 0.05 was considered statistically significant.
Results: The results indicated significant differences among groups in the rats' BUN and serum Cr 24 h after nephrectomy (P < 0.05). However, there were no significant differences in BUN, BSG, and Cr among groups after the interventions.
Conclusion: LAs did not affect renal function in single-kidney rats. Therefore, dentists can use the anesthetics in single-kidney people. |
| first_indexed | 2024-03-08T13:11:53Z |
| format | Article |
| id | doaj.art-02d67b99ec294f42903d28d4a1282c54 |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-03-08T13:11:53Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-02d67b99ec294f42903d28d4a1282c542024-01-18T11:19:50ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552023-01-01201106106Effect of local anesthetics on renal function: An animal study in IranRasul GheisariMasoud SaatchiFiroozeh EstakhriMehrdad VossoughiMohammad BazaeiZahra KhosravaniBackground: Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in single-kidney rats. Materials and Methods: The present experimental animal study with two control groups was done in an animal laboratory. Forty-two rats were randomly assigned to seven groups of six rats, including two control groups and five experimental groups. The experimental groups underwent intraperitoneal anesthesia with 2% lidocaine, 2% lidocaine with 1:80,000 epinephrine, 4% articaine, 3% prilocaine with 0.03 IU Felypressin, and 3% mepivacaine, respectively. Unilateral nephrectomy was done. After 24 h, the rats' blood urea nitrogen (BUN), serum creatinine (Cr), and blood specific gravity (BSG) were measured. A standard dose of anesthetics was injected into the peritoneum for 4 days afterward. Then, these indices were measured again 24 h after the last injection. Data were analyzed using IBM SPSS (version 21.0). One-way analysis of variance, Tukey's honestly significant difference post hoc, and paired t-tests were used for statistical analysis. P < 0.05 was considered statistically significant. Results: The results indicated significant differences among groups in the rats' BUN and serum Cr 24 h after nephrectomy (P < 0.05). However, there were no significant differences in BUN, BSG, and Cr among groups after the interventions. Conclusion: LAs did not affect renal function in single-kidney rats. Therefore, dentists can use the anesthetics in single-kidney people.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=106;epage=106;aulast=Gheisariarticainekidney function testlidocainelocal anesthesiamepivacaineprilocainesingle kidney |
| spellingShingle | Rasul Gheisari Masoud Saatchi Firoozeh Estakhri Mehrdad Vossoughi Mohammad Bazaei Zahra Khosravani Effect of local anesthetics on renal function: An animal study in Iran Dental Research Journal articaine kidney function test lidocaine local anesthesia mepivacaine prilocaine single kidney |
| title | Effect of local anesthetics on renal function: An animal study in Iran |
| title_full | Effect of local anesthetics on renal function: An animal study in Iran |
| title_fullStr | Effect of local anesthetics on renal function: An animal study in Iran |
| title_full_unstemmed | Effect of local anesthetics on renal function: An animal study in Iran |
| title_short | Effect of local anesthetics on renal function: An animal study in Iran |
| title_sort | effect of local anesthetics on renal function an animal study in iran |
| topic | articaine kidney function test lidocaine local anesthesia mepivacaine prilocaine single kidney |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=106;epage=106;aulast=Gheisari |
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