Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii

ABSTRACT Acinetobacter baumannii has become one of the most challenging pathogens in many countries with limited treatment options available. Cefiderocol, a novel siderophore-conjugated cephalosporin, shows potent in vitro activity against A. baumannii, including isolates resistant to carbapenems. T...

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Bibliographic Details
Main Authors: Xiaochen Liu, Yunjie Chang, Qingye Xu, Wang Zhang, Zhen Huang, Linyue Zhang, Shanshan Weng, Sebastian Leptihn, Yan Jiang, Yunsong Yu, Xiaoting Hua
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mSystems
Subjects:
BaeSR
cefiderocol resistance
MFS
MacAB-TolC
Csu pili
virulence
Online Access:https://journals.asm.org/doi/10.1128/msystems.01291-22

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