Efficacy of guided self-change for smoking cessation in chronic obstructive pulmonary disease patients: A randomized controlled clinical trial
Introduction The aim of this study was to examine the efficacy of guided selfchange (GSC), nicotine replacement therapy (NRT), and their combination, on smoking cessation among patients with COPD. Methods A total of 60 participants were randomly assigned to three groups for GSC (n=20), nicotine rep...
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| Format: | Article |
| Language: | English |
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European Publishing
2019-12-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/Efficacy-of-guided-self-change-for-smoking-cessation-in-chronic-obstructive-pulmonary,114227,0,2.html |
| _version_ | 1828909438857117696 |
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| author | Mehran Zarghami Fatemeh Taghizadeh Ali Sharifpour Abbas Alipour |
| author_facet | Mehran Zarghami Fatemeh Taghizadeh Ali Sharifpour Abbas Alipour |
| author_sort | Mehran Zarghami |
| collection | DOAJ |
| description | Introduction
The aim of this study was to examine the efficacy of guided selfchange
(GSC), nicotine replacement therapy (NRT), and their combination,
on smoking cessation among patients with COPD.
Methods
A total of 60 participants were randomly assigned to three groups
for GSC (n=20), nicotine replacement therapy (NRT) (n=20) or their
combination (n=20), from December 2016 to November 2017. The quality
of life (QoL) questionnaire, clinical assessment test (CAT) and exhaled
carbon monoxide (CO), were measured at baseline and post-treatment.
Results
At 6, 12, and 29 weeks, the abstinence rate in the NRT group was
5.3%, 15.8% and 21.1%, in the GSC group 21.1%, 31.6% and 47.4%, and in
the combined group 36.8%, 36.8% and 47.4%, respectively. The exhaled CO
in the NRT group was greater than the GSC group, however this difference
was not statistically significant (3.4; 95% CI: -0.24–7.0; p=0.067), CO levels
in the combined group were less than the GSC group, while this difference
was also not significant (-0.75; 95% CI : -4.2–2.7; p=0.68). CAT and QoL
recovery in the GSC and combined groups were higher than in the NRT
group (9.2; 95% CI: 5.0–13.4; p=0.001) and (-4.5; 95% C: -8.1– -0.6;
p=0.02), respectively. However, differences between combined and GSC
groups were not significant (p=0.24 and p=0.41, respectively). There was
a statistically significant difference between the abstinence rate in the GSC
or combined group and the NRT group (p=0.001). The GEE model showed
that GSC reduced the odds of smoking compared with the NRT group
(interaction group effect) (OR=0.31, 95% CI: 0.022–0.545; p=0.001).
Conclusions
In our context among COPD patients, GSC was more effective
in decreasing smoking than NRT alone. Moreover, the recovery of exhaled
carbon monoxide, CAT and QoL in GSC was more than in the NRT group.
Moreover, since GSC was as effective as GSC plus NRT, the effectiveness
of the combination method for smoking cessation in COPD patients may
be attributed to GSC.
Clinical trial registration details
IRCT201609271457N11; www.irct.ir |
| first_indexed | 2024-12-13T18:26:58Z |
| format | Article |
| id | doaj.art-02d9db15fdcb453fa2b37456e5c834e8 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-13T18:26:58Z |
| publishDate | 2019-12-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-02d9db15fdcb453fa2b37456e5c834e82022-12-21T23:35:34ZengEuropean PublishingTobacco Induced Diseases1617-96252019-12-0117December10.18332/tid/114227114227Efficacy of guided self-change for smoking cessation in chronic obstructive pulmonary disease patients: A randomized controlled clinical trialMehran Zarghami0Fatemeh Taghizadeh1Ali Sharifpour2Abbas Alipour3Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, IranPsychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IranPulmonary and Critical Care Division, Iranian National Registry Center for Lophomoniasis, Mazandaran University of Medical Sciences, Sari, IranDepartment of Epidemiology, Mazandaran University of Medical Sciences, Sari, IranIntroduction The aim of this study was to examine the efficacy of guided selfchange (GSC), nicotine replacement therapy (NRT), and their combination, on smoking cessation among patients with COPD. Methods A total of 60 participants were randomly assigned to three groups for GSC (n=20), nicotine replacement therapy (NRT) (n=20) or their combination (n=20), from December 2016 to November 2017. The quality of life (QoL) questionnaire, clinical assessment test (CAT) and exhaled carbon monoxide (CO), were measured at baseline and post-treatment. Results At 6, 12, and 29 weeks, the abstinence rate in the NRT group was 5.3%, 15.8% and 21.1%, in the GSC group 21.1%, 31.6% and 47.4%, and in the combined group 36.8%, 36.8% and 47.4%, respectively. The exhaled CO in the NRT group was greater than the GSC group, however this difference was not statistically significant (3.4; 95% CI: -0.24–7.0; p=0.067), CO levels in the combined group were less than the GSC group, while this difference was also not significant (-0.75; 95% CI : -4.2–2.7; p=0.68). CAT and QoL recovery in the GSC and combined groups were higher than in the NRT group (9.2; 95% CI: 5.0–13.4; p=0.001) and (-4.5; 95% C: -8.1– -0.6; p=0.02), respectively. However, differences between combined and GSC groups were not significant (p=0.24 and p=0.41, respectively). There was a statistically significant difference between the abstinence rate in the GSC or combined group and the NRT group (p=0.001). The GEE model showed that GSC reduced the odds of smoking compared with the NRT group (interaction group effect) (OR=0.31, 95% CI: 0.022–0.545; p=0.001). Conclusions In our context among COPD patients, GSC was more effective in decreasing smoking than NRT alone. Moreover, the recovery of exhaled carbon monoxide, CAT and QoL in GSC was more than in the NRT group. Moreover, since GSC was as effective as GSC plus NRT, the effectiveness of the combination method for smoking cessation in COPD patients may be attributed to GSC. Clinical trial registration details IRCT201609271457N11; www.irct.irhttp://www.journalssystem.com/tid/Efficacy-of-guided-self-change-for-smoking-cessation-in-chronic-obstructive-pulmonary,114227,0,2.htmlquality of lifesmoking cessationchronic obstructive pulmonary disease |
| spellingShingle | Mehran Zarghami Fatemeh Taghizadeh Ali Sharifpour Abbas Alipour Efficacy of guided self-change for smoking cessation in chronic obstructive pulmonary disease patients: A randomized controlled clinical trial Tobacco Induced Diseases quality of life smoking cessation chronic obstructive pulmonary disease |
| title | Efficacy of guided self-change for smoking cessation in
chronic obstructive pulmonary disease patients: A randomized
controlled clinical trial |
| title_full | Efficacy of guided self-change for smoking cessation in
chronic obstructive pulmonary disease patients: A randomized
controlled clinical trial |
| title_fullStr | Efficacy of guided self-change for smoking cessation in
chronic obstructive pulmonary disease patients: A randomized
controlled clinical trial |
| title_full_unstemmed | Efficacy of guided self-change for smoking cessation in
chronic obstructive pulmonary disease patients: A randomized
controlled clinical trial |
| title_short | Efficacy of guided self-change for smoking cessation in
chronic obstructive pulmonary disease patients: A randomized
controlled clinical trial |
| title_sort | efficacy of guided self change for smoking cessation in chronic obstructive pulmonary disease patients a randomized controlled clinical trial |
| topic | quality of life smoking cessation chronic obstructive pulmonary disease |
| url | http://www.journalssystem.com/tid/Efficacy-of-guided-self-change-for-smoking-cessation-in-chronic-obstructive-pulmonary,114227,0,2.html |
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