Antiandrogens as Therapies for COVID-19: A Systematic Review
Background: In 2019, the breakthrough of the coronavirus 2 disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represented one of the major issues of our recent history. Different drugs have been tested to rapidly find effective anti-viral treatme...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/2/298 |
| _version_ | 1797344457781149696 |
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| author | Massimiliano Cani Samantha Epistolio Giulia Dazio Mikol Modesti Giuseppe Salfi Martino Pedrani Luca Isella Silke Gillessen Ursula Maria Vogl Luigi Tortola Giorgio Treglia Consuelo Buttigliero Milo Frattini Ricardo Pereira Mestre |
| author_facet | Massimiliano Cani Samantha Epistolio Giulia Dazio Mikol Modesti Giuseppe Salfi Martino Pedrani Luca Isella Silke Gillessen Ursula Maria Vogl Luigi Tortola Giorgio Treglia Consuelo Buttigliero Milo Frattini Ricardo Pereira Mestre |
| author_sort | Massimiliano Cani |
| collection | DOAJ |
| description | Background: In 2019, the breakthrough of the coronavirus 2 disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represented one of the major issues of our recent history. Different drugs have been tested to rapidly find effective anti-viral treatments and, among these, antiandrogens have been suggested to play a role in mediating SARS-CoV-2 infection. Considering the high heterogeneity of studies on this topic, we decided to review the current literature. Methods: We performed a systematic review according to PRISMA guidelines. A search strategy was conducted on PUBMED and Medline. Only original articles published from March 2020 to 31 August 2023 investigating the possible protective role of antiandrogens were included. In vitro or preclinical studies and reports not in the English language were excluded. The main objective was to investigate how antiandrogens may interfere with COVID-19 outcomes. Results: Among 1755 records, we selected 31 studies, the majority of which consisted of retrospective clinical data collections and of randomized clinical trials during the first and second wave of the COVID-19 pandemic. Conclusions: In conclusion, we can state that antiandrogens do not seem to protect individuals from SARS-CoV-2 infection and COVID-19 severity and, thus, their use should not be encouraged in this field. |
| first_indexed | 2024-03-08T11:02:53Z |
| format | Article |
| id | doaj.art-02db229ae4cd4b27a76ba2306d6a63df |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:02:53Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-02db229ae4cd4b27a76ba2306d6a63df2024-01-26T15:35:19ZengMDPI AGCancers2072-66942024-01-0116229810.3390/cancers16020298Antiandrogens as Therapies for COVID-19: A Systematic ReviewMassimiliano Cani0Samantha Epistolio1Giulia Dazio2Mikol Modesti3Giuseppe Salfi4Martino Pedrani5Luca Isella6Silke Gillessen7Ursula Maria Vogl8Luigi Tortola9Giorgio Treglia10Consuelo Buttigliero11Milo Frattini12Ricardo Pereira Mestre13Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandLaboratory of Genetics and Molecular Pathology, Institute of Pathology, Ente Ospedaliero Cantonale (EOC), 6600 Locarno, SwitzerlandLaboratory of Genetics and Molecular Pathology, Institute of Pathology, Ente Ospedaliero Cantonale (EOC), 6600 Locarno, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandFaculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandOncology Unit, Department of Oncology, University of Turin, S. Luigi Gonzaga Hospital, 10043 Orbassano, ItalyLaboratory of Genetics and Molecular Pathology, Institute of Pathology, Ente Ospedaliero Cantonale (EOC), 6600 Locarno, SwitzerlandOncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, SwitzerlandBackground: In 2019, the breakthrough of the coronavirus 2 disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represented one of the major issues of our recent history. Different drugs have been tested to rapidly find effective anti-viral treatments and, among these, antiandrogens have been suggested to play a role in mediating SARS-CoV-2 infection. Considering the high heterogeneity of studies on this topic, we decided to review the current literature. Methods: We performed a systematic review according to PRISMA guidelines. A search strategy was conducted on PUBMED and Medline. Only original articles published from March 2020 to 31 August 2023 investigating the possible protective role of antiandrogens were included. In vitro or preclinical studies and reports not in the English language were excluded. The main objective was to investigate how antiandrogens may interfere with COVID-19 outcomes. Results: Among 1755 records, we selected 31 studies, the majority of which consisted of retrospective clinical data collections and of randomized clinical trials during the first and second wave of the COVID-19 pandemic. Conclusions: In conclusion, we can state that antiandrogens do not seem to protect individuals from SARS-CoV-2 infection and COVID-19 severity and, thus, their use should not be encouraged in this field.https://www.mdpi.com/2072-6694/16/2/298COVID-19SARS-CoV-2antiandrogenstestosterone |
| spellingShingle | Massimiliano Cani Samantha Epistolio Giulia Dazio Mikol Modesti Giuseppe Salfi Martino Pedrani Luca Isella Silke Gillessen Ursula Maria Vogl Luigi Tortola Giorgio Treglia Consuelo Buttigliero Milo Frattini Ricardo Pereira Mestre Antiandrogens as Therapies for COVID-19: A Systematic Review Cancers COVID-19 SARS-CoV-2 antiandrogens testosterone |
| title | Antiandrogens as Therapies for COVID-19: A Systematic Review |
| title_full | Antiandrogens as Therapies for COVID-19: A Systematic Review |
| title_fullStr | Antiandrogens as Therapies for COVID-19: A Systematic Review |
| title_full_unstemmed | Antiandrogens as Therapies for COVID-19: A Systematic Review |
| title_short | Antiandrogens as Therapies for COVID-19: A Systematic Review |
| title_sort | antiandrogens as therapies for covid 19 a systematic review |
| topic | COVID-19 SARS-CoV-2 antiandrogens testosterone |
| url | https://www.mdpi.com/2072-6694/16/2/298 |
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