Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study
(1) Background: Irritable bowel syndrome (IBS) is a common disease, with multiple pathophysiological mechanisms involved. A single treatment for all the patients with IBS is not possible. Prebiotics may have a beneficial effect on IBS patients with constipation. (2) Methods: A randomized cross-over...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/8/2248 |
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| author | Oana-Bogdana Bărboi Ioan Chirilă Irina Ciortescu Carmen Anton Vasile-Liviu Drug |
| author_facet | Oana-Bogdana Bărboi Ioan Chirilă Irina Ciortescu Carmen Anton Vasile-Liviu Drug |
| author_sort | Oana-Bogdana Bărboi |
| collection | DOAJ |
| description | (1) Background: Irritable bowel syndrome (IBS) is a common disease, with multiple pathophysiological mechanisms involved. A single treatment for all the patients with IBS is not possible. Prebiotics may have a beneficial effect on IBS patients with constipation. (2) Methods: A randomized cross-over case-control study was conducted, including patients with IBS and constipation (IBS-C), who were randomized into two groups receiving a specific constipation diet with or without a food supplement containing inulin, choline and silymarin (Stoptoxin<sup>®</sup>, Fiterman Pharma, Iasi, Romania). Patients were evaluated at baseline, after four and eight weeks, using a questionnaire to assess IBS symptoms. (3) Results: 51 IBS-C patients were included, of which 47 patients finished the trial (33 women, mean age 52.82 years). Adding Stoptoxin<sup>®</sup> to a diet for constipation brought extra benefits. Abdominal pain severity improved by 68.3% after the diet and Stoptoxin<sup>®</sup> (<i>p</i> = 0.004) and abdominal bloating severity parameter improved by 34.8% (<i>p</i> = 0.040). The stool number per week and the stool consistency according to the Bristol scale were improved, but without statistical significance between groups (<i>p</i> > 0.05). (4) Conclusions: The combination of inulin, choline and silymarin associated with a specific-constipation diet had obvious clinical beneficial effects on IBS-C patients in terms of bowel movement, abdominal pain and bloating. |
| first_indexed | 2024-03-09T04:32:33Z |
| format | Article |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:32:33Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-02dc318f469d4660b4c2371810e7bb502023-12-03T13:33:12ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118224810.3390/jcm11082248Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control StudyOana-Bogdana Bărboi0Ioan Chirilă1Irina Ciortescu2Carmen Anton3Vasile-Liviu Drug4Department of Gastroenterology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaEnvironmental Health Department, National Institute of Public Health—RCoPH, 700465 Iasi, RomaniaDepartment of Gastroenterology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Gastroenterology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Gastroenterology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania(1) Background: Irritable bowel syndrome (IBS) is a common disease, with multiple pathophysiological mechanisms involved. A single treatment for all the patients with IBS is not possible. Prebiotics may have a beneficial effect on IBS patients with constipation. (2) Methods: A randomized cross-over case-control study was conducted, including patients with IBS and constipation (IBS-C), who were randomized into two groups receiving a specific constipation diet with or without a food supplement containing inulin, choline and silymarin (Stoptoxin<sup>®</sup>, Fiterman Pharma, Iasi, Romania). Patients were evaluated at baseline, after four and eight weeks, using a questionnaire to assess IBS symptoms. (3) Results: 51 IBS-C patients were included, of which 47 patients finished the trial (33 women, mean age 52.82 years). Adding Stoptoxin<sup>®</sup> to a diet for constipation brought extra benefits. Abdominal pain severity improved by 68.3% after the diet and Stoptoxin<sup>®</sup> (<i>p</i> = 0.004) and abdominal bloating severity parameter improved by 34.8% (<i>p</i> = 0.040). The stool number per week and the stool consistency according to the Bristol scale were improved, but without statistical significance between groups (<i>p</i> > 0.05). (4) Conclusions: The combination of inulin, choline and silymarin associated with a specific-constipation diet had obvious clinical beneficial effects on IBS-C patients in terms of bowel movement, abdominal pain and bloating.https://www.mdpi.com/2077-0383/11/8/2248irritable bowel syndromeconstipationinulincholinesilymarin |
| spellingShingle | Oana-Bogdana Bărboi Ioan Chirilă Irina Ciortescu Carmen Anton Vasile-Liviu Drug Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study Journal of Clinical Medicine irritable bowel syndrome constipation inulin choline silymarin |
| title | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study |
| title_full | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study |
| title_fullStr | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study |
| title_full_unstemmed | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study |
| title_short | Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation—Randomized Case-Control Study |
| title_sort | inulin choline and silymarin in the treatment of irritable bowel syndrome with constipation randomized case control study |
| topic | irritable bowel syndrome constipation inulin choline silymarin |
| url | https://www.mdpi.com/2077-0383/11/8/2248 |
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