A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels

A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels

Abstract Background Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children. Its pathogenesis is unknown. In this disease, symptoms resolve spontaneously in approximately 50% of patients when maturity is reached, prompting to a maturation problem. The purpose of this...

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Main Authors: Mariana L. Casalia, Juan Cruz Casabona, Corina García, Verónica Cavaliere Candedo, Héctor Ramiro Quintá, María Isabel Farías, Joaquín Gonzalez, Dolores Gonzalez Morón, Marta Córdoba, Damian Consalvo, Gustavo Mostoslavsky, Francisco J. Urbano, Juana Pasquini, Mario Gustavo Murer, Lorena Rela, Marcelo A. Kauffman, Fernando J. Pitossi
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Stem Cell Research & Therapy
Online Access:https://doi.org/10.1186/s13287-021-02658-2

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