Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice
Background: The bone marrow is frequently involved in variety of cases presenting with hematological and non-hematological disorders, which are diagnosed by two separate but interrelated techniques such as bone marrow aspiration (BMA) and bone marrow biopsy (BMB). Aim: This study was aimed to a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4760/9823_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: The bone marrow is frequently involved in variety
of cases presenting with hematological and non-hematological
disorders, which are diagnosed by two separate but interrelated
techniques such as bone marrow aspiration (BMA) and bone
marrow biopsy (BMB).
Aim: This study was aimed to assess the diagnostic value of the
BMA and BMB and role of both the procedures to reach final
diagnosis when done simultaneously.
Settings and Design: It was a prospective study. The findings
of BMA smears were correlated with BMB sections and data
obtained was analysed.
Materials and Methods: BMA and BMB were performed on 50
patients. Criteria of inclusion included the main indications for
performing this procedure, the availability of full medical records
and patient consent. The patients had a male to female sex ratio
of 1.6:1 and a wide age range from 4 years to 74 years.
Results: In the present study, the main indications for bone
marrow examination were categorized. Out of 50 cases
studied, in 23 cases, a strong positive correlation between BMA
and BMB was noted. However, it was found that in the cases
of aplastic anaemia, different phases of myeloproliferative
neoplasm (MPN), multiple myeloma, tubercular granulomas and
hemato-lymphoid neoplasm, involvement of the marrow was
detected better in bone marrow biopsies.
Conclusion: The study concludes that preparations of aspirate
and trephine biopsy are easy, rapid and complementary
to each other in majority of the lesions. The advantage of
both the procedures done together enabled us to study the
cytomorphology of the cells along with the pattern of distribution
of the cells depending on the cases, hence help in making the
diagnosis accurately. |
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| ISSN: | 2249-782X 0973-709X |