Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice
Background: The bone marrow is frequently involved in variety of cases presenting with hematological and non-hematological disorders, which are diagnosed by two separate but interrelated techniques such as bone marrow aspiration (BMA) and bone marrow biopsy (BMB). Aim: This study was aimed to a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4760/9823_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818758441833857024 |
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| author | Manjit Kaur Amrit Pal Singh Rana Shivali Kapoor Arun Puri |
| author_facet | Manjit Kaur Amrit Pal Singh Rana Shivali Kapoor Arun Puri |
| author_sort | Manjit Kaur |
| collection | DOAJ |
| description | Background: The bone marrow is frequently involved in variety
of cases presenting with hematological and non-hematological
disorders, which are diagnosed by two separate but interrelated
techniques such as bone marrow aspiration (BMA) and bone
marrow biopsy (BMB).
Aim: This study was aimed to assess the diagnostic value of the
BMA and BMB and role of both the procedures to reach final
diagnosis when done simultaneously.
Settings and Design: It was a prospective study. The findings
of BMA smears were correlated with BMB sections and data
obtained was analysed.
Materials and Methods: BMA and BMB were performed on 50
patients. Criteria of inclusion included the main indications for
performing this procedure, the availability of full medical records
and patient consent. The patients had a male to female sex ratio
of 1.6:1 and a wide age range from 4 years to 74 years.
Results: In the present study, the main indications for bone
marrow examination were categorized. Out of 50 cases
studied, in 23 cases, a strong positive correlation between BMA
and BMB was noted. However, it was found that in the cases
of aplastic anaemia, different phases of myeloproliferative
neoplasm (MPN), multiple myeloma, tubercular granulomas and
hemato-lymphoid neoplasm, involvement of the marrow was
detected better in bone marrow biopsies.
Conclusion: The study concludes that preparations of aspirate
and trephine biopsy are easy, rapid and complementary
to each other in majority of the lesions. The advantage of
both the procedures done together enabled us to study the
cytomorphology of the cells along with the pattern of distribution
of the cells depending on the cases, hence help in making the
diagnosis accurately. |
| first_indexed | 2024-12-18T06:26:53Z |
| format | Article |
| id | doaj.art-02debe82f59b4682a0d6f4efbad31d40 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-18T06:26:53Z |
| publishDate | 2014-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-02debe82f59b4682a0d6f4efbad31d402022-12-21T21:18:00ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-08-0188FC13FC1610.7860/JCDR/2014/9823.4760Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology PracticeManjit Kaur0Amrit Pal Singh Rana1Shivali Kapoor2Arun Puri3Assistant Professor, Department of Pathology, Guru Gobind Singh Medical College, Faridkot, India.Assistant Professor, Department of Surgery, Guru Gobind Singh Medical College, Faridkot, India.Pathologist, Lister Metropolis, Chennai, India.Professor, Department of Pathology, Guru Gobind Singh Medical College, Faridkot, India.Background: The bone marrow is frequently involved in variety of cases presenting with hematological and non-hematological disorders, which are diagnosed by two separate but interrelated techniques such as bone marrow aspiration (BMA) and bone marrow biopsy (BMB). Aim: This study was aimed to assess the diagnostic value of the BMA and BMB and role of both the procedures to reach final diagnosis when done simultaneously. Settings and Design: It was a prospective study. The findings of BMA smears were correlated with BMB sections and data obtained was analysed. Materials and Methods: BMA and BMB were performed on 50 patients. Criteria of inclusion included the main indications for performing this procedure, the availability of full medical records and patient consent. The patients had a male to female sex ratio of 1.6:1 and a wide age range from 4 years to 74 years. Results: In the present study, the main indications for bone marrow examination were categorized. Out of 50 cases studied, in 23 cases, a strong positive correlation between BMA and BMB was noted. However, it was found that in the cases of aplastic anaemia, different phases of myeloproliferative neoplasm (MPN), multiple myeloma, tubercular granulomas and hemato-lymphoid neoplasm, involvement of the marrow was detected better in bone marrow biopsies. Conclusion: The study concludes that preparations of aspirate and trephine biopsy are easy, rapid and complementary to each other in majority of the lesions. The advantage of both the procedures done together enabled us to study the cytomorphology of the cells along with the pattern of distribution of the cells depending on the cases, hence help in making the diagnosis accurately.https://jcdr.net/articles/PDF/4760/9823_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(AK)_PF2(PAG).pdfbone marrow aspirationbone marrow trephine biopsybone marrow examination |
| spellingShingle | Manjit Kaur Amrit Pal Singh Rana Shivali Kapoor Arun Puri Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice Journal of Clinical and Diagnostic Research bone marrow aspiration bone marrow trephine biopsy bone marrow examination |
| title | Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice |
| title_full | Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice |
| title_fullStr | Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice |
| title_full_unstemmed | Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice |
| title_short | Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice |
| title_sort | diagnostic value of bone marrow aspiration and biopsy in routine hematology practice |
| topic | bone marrow aspiration bone marrow trephine biopsy bone marrow examination |
| url | https://jcdr.net/articles/PDF/4760/9823_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(AK)_PF2(PAG).pdf |
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