Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible?
Creatinine, although widely used as a biomarker to measure renal function, has long been known as an insensitive marker of renal impairment. Patients with reduced renal function can have a creatinine level within the normal range, with a rapid rise when renal function is significantly reduced. As of...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2016-07-01
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| Series: | European Medical Journal Nephrology |
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| Online Access: | http://emjreviews.com/wp-content/uploads/Automatic-Reporting-of-Creatinine-Based-Estimated-Glomerular-Filtration-Rate-in-Children-Is-This-Feasible..1.pdf |
| _version_ | 1818362048694714368 |
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| author | Andrew Lunn |
| author_facet | Andrew Lunn |
| author_sort | Andrew Lunn |
| collection | DOAJ |
| description | Creatinine, although widely used as a biomarker to measure renal function, has long been known as an insensitive marker of renal impairment. Patients with reduced renal function can have a creatinine level within the normal range, with a rapid rise when renal function is significantly reduced. As of 1976, the correlation between height, the reciprocal of creatinine, and measured glomerular filtration rate (GFR) in children has been described. It has been used to derive a simple formula for estimated glomerular filtration rate (eGFR) that could be used at the bedside as a more sensitive method of identifying children with renal impairment. Formulae based on this association, with modifications over time as creatinine assay methods have changed, are still widely used clinically at the bedside and in research studies to assess the degree of renal impairment in children.
Adult practice has moved in many countries to computer-generated results that report eGFR alongside creatinine results using more complex, but potentially more accurate estimates of GFR, which are independent of height. This permits early identification of patients with chronic kidney disease. This review assesses the feasibility of automated reporting of eGFR and the advantages and disadvantages of this in children. |
| first_indexed | 2024-12-13T21:26:23Z |
| format | Article |
| id | doaj.art-02df292c99334110a9b57639c9883668 |
| institution | Directory Open Access Journal |
| issn | 2053-4248 |
| language | English |
| last_indexed | 2024-12-13T21:26:23Z |
| publishDate | 2016-07-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Nephrology |
| spelling | doaj.art-02df292c99334110a9b57639c98836682022-12-21T23:30:56ZengEuropean Medical JournalEuropean Medical Journal Nephrology2053-42482016-07-0141106112Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible?Andrew Lunn0The Children’s Renal and Urology Unit, Nottingham Children’s Hospital, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Nottingham, UKCreatinine, although widely used as a biomarker to measure renal function, has long been known as an insensitive marker of renal impairment. Patients with reduced renal function can have a creatinine level within the normal range, with a rapid rise when renal function is significantly reduced. As of 1976, the correlation between height, the reciprocal of creatinine, and measured glomerular filtration rate (GFR) in children has been described. It has been used to derive a simple formula for estimated glomerular filtration rate (eGFR) that could be used at the bedside as a more sensitive method of identifying children with renal impairment. Formulae based on this association, with modifications over time as creatinine assay methods have changed, are still widely used clinically at the bedside and in research studies to assess the degree of renal impairment in children. Adult practice has moved in many countries to computer-generated results that report eGFR alongside creatinine results using more complex, but potentially more accurate estimates of GFR, which are independent of height. This permits early identification of patients with chronic kidney disease. This review assesses the feasibility of automated reporting of eGFR and the advantages and disadvantages of this in children.http://emjreviews.com/wp-content/uploads/Automatic-Reporting-of-Creatinine-Based-Estimated-Glomerular-Filtration-Rate-in-Children-Is-This-Feasible..1.pdfautomated reporting of eGFRchildrenchronic kidney disease (CKD)Estimated glomerular filtration rate (eGFR) |
| spellingShingle | Andrew Lunn Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? European Medical Journal Nephrology automated reporting of eGFR children chronic kidney disease (CKD) Estimated glomerular filtration rate (eGFR) |
| title | Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? |
| title_full | Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? |
| title_fullStr | Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? |
| title_full_unstemmed | Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? |
| title_short | Automatic Reporting of Creatinine-Based Estimated Glomerular Filtration Rate in Children: Is this Feasible? |
| title_sort | automatic reporting of creatinine based estimated glomerular filtration rate in children is this feasible |
| topic | automated reporting of eGFR children chronic kidney disease (CKD) Estimated glomerular filtration rate (eGFR) |
| url | http://emjreviews.com/wp-content/uploads/Automatic-Reporting-of-Creatinine-Based-Estimated-Glomerular-Filtration-Rate-in-Children-Is-This-Feasible..1.pdf |
| work_keys_str_mv | AT andrewlunn automaticreportingofcreatininebasedestimatedglomerularfiltrationrateinchildrenisthisfeasible |