Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection
Background/Aims: Symptom-based subtyping of functional dyspepsia (FD) is used to segregate patients into groups with homogenous pathophysiological mechanisms. This study examined whether subtyping could reflect the duodenal and gastric microinflammation in FD patients. Methods: Twenty-one FD patien...
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2022-07-01
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| Series: | The Korean Journal of Gastroenterology |
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| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5835&vmd=Full |
| _version_ | 1797272327662075904 |
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| author | Yang Won Min Hyuk Lee Soomin Ahn Kyung Ho Song Jong Kyu Park Cheol Min Shin Kyu Chan Huh Functional Dyspepsia Study Group Under the Korean Society of Neurogastroenterology and Motility |
| author_facet | Yang Won Min Hyuk Lee Soomin Ahn Kyung Ho Song Jong Kyu Park Cheol Min Shin Kyu Chan Huh Functional Dyspepsia Study Group Under the Korean Society of Neurogastroenterology and Motility |
| author_sort | Yang Won Min |
| collection | DOAJ |
| description | Background/Aims: Symptom-based subtyping of functional dyspepsia (FD) is used to segregate patients into groups with homogenous pathophysiological mechanisms. This study examined whether subtyping could reflect the duodenal and gastric microinflammation in FD patients.
Methods: Twenty-one FD patients without Helicobacter pylori infection were recruited. An endoscopic biopsy was performed in the duodenum 2nd portion, stomach antrum, and body. The eosinophil and mast cell counts per high-power field (×40) were investigated by H&E and c-kit staining, respectively. The degree of inflammatory cell infiltration, atrophy, and intestinal metaplasia was also determined by H&E staining in the stomach. The baseline characteristics and eosinophil and mast cell infiltrations were compared among the three groups (epigastric pain syndrome, postprandial distress syndrome, and overlap).
Results: According to the symptom assessment, seven subjects were classified into the epigastric pain syndrome group, 10 into the postprandial syndrome group, and four into the overlap group. The baseline variables were similar in the three groups. Eosinophil infiltration was more prominent in the duodenum than in the stomach. In contrast, mast cell infiltration was similar in the duodenum and stomach. The eosinophil counts in the duodenum were similar in the three groups. The eosinophil counts in the stomach and mast cell counts in the duodenum and stomach were also similar in the three groups.
Conclusions: Duodenal eosinophil infiltration was prominent in FD patients, but the eosinophil counts were similar regardless of the symptom-based subtypes of FD. Hence, the current symptom-based subtyping of FD does not reflect duodenal eosinophil and mast cell infiltration. |
| first_indexed | 2024-03-07T14:26:45Z |
| format | Article |
| id | doaj.art-02e133ab591047789e34309e008d37ea |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-03-07T14:26:45Z |
| publishDate | 2022-07-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-02e133ab591047789e34309e008d37ea2024-03-06T06:16:01ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692022-07-01801283310.4166/kjg.2022.036Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infectionYang Won Min0Hyuk Lee1Soomin Ahn2Kyung Ho Song3Jong Kyu Park4Cheol Min Shin5Kyu Chan Huh6Functional Dyspepsia Study Group Under the Korean Society of Neurogastroenterology and MotilityDepartments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartments of Medicine, Pathology and Translational Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, CHA Ilsan Medical Center, CHA University, School of Medicine, Goyang, KoreaDepartment of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine, Konyang University College of Medicine, Daejeon, KoreaBackground/Aims: Symptom-based subtyping of functional dyspepsia (FD) is used to segregate patients into groups with homogenous pathophysiological mechanisms. This study examined whether subtyping could reflect the duodenal and gastric microinflammation in FD patients. Methods: Twenty-one FD patients without Helicobacter pylori infection were recruited. An endoscopic biopsy was performed in the duodenum 2nd portion, stomach antrum, and body. The eosinophil and mast cell counts per high-power field (×40) were investigated by H&E and c-kit staining, respectively. The degree of inflammatory cell infiltration, atrophy, and intestinal metaplasia was also determined by H&E staining in the stomach. The baseline characteristics and eosinophil and mast cell infiltrations were compared among the three groups (epigastric pain syndrome, postprandial distress syndrome, and overlap). Results: According to the symptom assessment, seven subjects were classified into the epigastric pain syndrome group, 10 into the postprandial syndrome group, and four into the overlap group. The baseline variables were similar in the three groups. Eosinophil infiltration was more prominent in the duodenum than in the stomach. In contrast, mast cell infiltration was similar in the duodenum and stomach. The eosinophil counts in the duodenum were similar in the three groups. The eosinophil counts in the stomach and mast cell counts in the duodenum and stomach were also similar in the three groups. Conclusions: Duodenal eosinophil infiltration was prominent in FD patients, but the eosinophil counts were similar regardless of the symptom-based subtypes of FD. Hence, the current symptom-based subtyping of FD does not reflect duodenal eosinophil and mast cell infiltration.https://www.kjg.or.kr/journal/view.html?uid=5835&vmd=Fullduodenumdyspepsiaeosinophilsmast cellsupper gastrointestinal tract |
| spellingShingle | Yang Won Min Hyuk Lee Soomin Ahn Kyung Ho Song Jong Kyu Park Cheol Min Shin Kyu Chan Huh Functional Dyspepsia Study Group Under the Korean Society of Neurogastroenterology and Motility Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection The Korean Journal of Gastroenterology duodenum dyspepsia eosinophils mast cells upper gastrointestinal tract |
| title | Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection |
| title_full | Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection |
| title_fullStr | Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection |
| title_full_unstemmed | Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection |
| title_short | Eosinophil and Mast Cell Counts in the Stomach and Duodenum of Patients with Functional Dyspepsia without a Helicobacter pylori infection |
| title_sort | eosinophil and mast cell counts in the stomach and duodenum of patients with functional dyspepsia without a helicobacter pylori infection |
| topic | duodenum dyspepsia eosinophils mast cells upper gastrointestinal tract |
| url | https://www.kjg.or.kr/journal/view.html?uid=5835&vmd=Full |
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