Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.DESIGN AND...
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600364&lng=en&tlng=en |
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| author | Aline Ventura Marcelo Fernando Ronsoni Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Maria Heloisa Busi da Silva Canalli Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon |
| author_facet | Aline Ventura Marcelo Fernando Ronsoni Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Maria Heloisa Busi da Silva Canalli Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon |
| author_sort | Aline Ventura |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.DESIGN AND SETTING: Cross-sectional study in a public university hospital.METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011.RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy.CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence. |
| first_indexed | 2024-12-13T02:23:36Z |
| format | Article |
| id | doaj.art-02e20d6b512c4653ab3357c95b41402c |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-13T02:23:36Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-02e20d6b512c4653ab3357c95b41402c2022-12-22T00:02:42ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460132636437110.1590/1516-3180.2014.1326725S1516-31802014000600364Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional studyAline VenturaMarcelo Fernando RonsoniMaria Beatriz Cacese ShiozawaEsther Buzaglo Dantas-CorrêaMaria Heloisa Busi da Silva CanalliLeonardo de Lucca SchiavonJanaína Luz Narciso-SchiavonCONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.DESIGN AND SETTING: Cross-sectional study in a public university hospital.METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011.RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy.CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600364&lng=en&tlng=enCeliac diseaseThyroiditis, autoimmuneTransglutaminasesBiopsyHashimoto disease |
| spellingShingle | Aline Ventura Marcelo Fernando Ronsoni Maria Beatriz Cacese Shiozawa Esther Buzaglo Dantas-Corrêa Maria Heloisa Busi da Silva Canalli Leonardo de Lucca Schiavon Janaína Luz Narciso-Schiavon Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study São Paulo Medical Journal Celiac disease Thyroiditis, autoimmune Transglutaminases Biopsy Hashimoto disease |
| title | Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study |
| title_full | Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study |
| title_fullStr | Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study |
| title_full_unstemmed | Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study |
| title_short | Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study |
| title_sort | prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis cross sectional study |
| topic | Celiac disease Thyroiditis, autoimmune Transglutaminases Biopsy Hashimoto disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600364&lng=en&tlng=en |
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