Is there any role of staging laparoscopy in pancreatic adenocarcinoma?
Abstract This is a letter to the editor on a study by Jambor et al. on the role of staging laparoscopy in identifying occult and distant metastases in pancreatic adenocarcinoma patients. In this study, inclusion of staging laparoscopy as an adjunct to computed tomography resulted in an absolute risk...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-02975-1 |
| _version_ | 1797822779657027584 |
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| author | Theresa Soni Jaiveer Singh Bharath Nagarajan Priyadarshini Velmurugan Sudharsanan Sundaramurthi |
| author_facet | Theresa Soni Jaiveer Singh Bharath Nagarajan Priyadarshini Velmurugan Sudharsanan Sundaramurthi |
| author_sort | Theresa Soni |
| collection | DOAJ |
| description | Abstract This is a letter to the editor on a study by Jambor et al. on the role of staging laparoscopy in identifying occult and distant metastases in pancreatic adenocarcinoma patients. In this study, inclusion of staging laparoscopy as an adjunct to computed tomography resulted in an absolute risk reduction of 12.5% for non-therapeutic laparotomy. The study found no correlation between the presence of occult and distant metastases, and serum CA 19-9 level, tumour size or location, which was in significant contrast to a number of other studies. This was likely due to the smaller sample size of the study and restriction to a single high-volume referral centre. It is also noted that staging laparoscopy cannot detect vascular invasion, lymph node involvement and deep hepatic metastases. The sensitivity of peritoneal lavage cytology in detecting occult metastases is low as well. Inclusion of biomarkers like peritoneal lavage tumour DNA may improve sensitivity. Hence, even as this study adds to the evidence supporting staging laparoscopy, further studies on improving the sensitivity of staging laparoscopy are warranted. |
| first_indexed | 2024-03-13T10:14:12Z |
| format | Article |
| id | doaj.art-02e4b27cb3c04b4c8d623a8cee487b74 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-13T10:14:12Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-02e4b27cb3c04b4c8d623a8cee487b742023-05-21T11:18:02ZengBMCWorld Journal of Surgical Oncology1477-78192023-05-012111210.1186/s12957-023-02975-1Is there any role of staging laparoscopy in pancreatic adenocarcinoma?Theresa Soni0Jaiveer Singh1Bharath Nagarajan2Priyadarshini Velmurugan3Sudharsanan Sundaramurthi4Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)Abstract This is a letter to the editor on a study by Jambor et al. on the role of staging laparoscopy in identifying occult and distant metastases in pancreatic adenocarcinoma patients. In this study, inclusion of staging laparoscopy as an adjunct to computed tomography resulted in an absolute risk reduction of 12.5% for non-therapeutic laparotomy. The study found no correlation between the presence of occult and distant metastases, and serum CA 19-9 level, tumour size or location, which was in significant contrast to a number of other studies. This was likely due to the smaller sample size of the study and restriction to a single high-volume referral centre. It is also noted that staging laparoscopy cannot detect vascular invasion, lymph node involvement and deep hepatic metastases. The sensitivity of peritoneal lavage cytology in detecting occult metastases is low as well. Inclusion of biomarkers like peritoneal lavage tumour DNA may improve sensitivity. Hence, even as this study adds to the evidence supporting staging laparoscopy, further studies on improving the sensitivity of staging laparoscopy are warranted.https://doi.org/10.1186/s12957-023-02975-1Pancreatic adenocarcinomaStaging laparoscopyCA 19-9Pancreatic surgery |
| spellingShingle | Theresa Soni Jaiveer Singh Bharath Nagarajan Priyadarshini Velmurugan Sudharsanan Sundaramurthi Is there any role of staging laparoscopy in pancreatic adenocarcinoma? World Journal of Surgical Oncology Pancreatic adenocarcinoma Staging laparoscopy CA 19-9 Pancreatic surgery |
| title | Is there any role of staging laparoscopy in pancreatic adenocarcinoma? |
| title_full | Is there any role of staging laparoscopy in pancreatic adenocarcinoma? |
| title_fullStr | Is there any role of staging laparoscopy in pancreatic adenocarcinoma? |
| title_full_unstemmed | Is there any role of staging laparoscopy in pancreatic adenocarcinoma? |
| title_short | Is there any role of staging laparoscopy in pancreatic adenocarcinoma? |
| title_sort | is there any role of staging laparoscopy in pancreatic adenocarcinoma |
| topic | Pancreatic adenocarcinoma Staging laparoscopy CA 19-9 Pancreatic surgery |
| url | https://doi.org/10.1186/s12957-023-02975-1 |
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