Free-radical oxidation as a pathogenetic factor of metabolic syndrome
The medical and social significance of cardiovascular diseases remains high. One of the factors that determine cardiovascular risks is metabolic syndrome. As a result of excessive accumulation of lipid and carbohydrate metabolism products in metabolic syndrome, oxidative (oxidative) stress develops....
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2023-01-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12804 |
| _version_ | 1797204510130569216 |
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| author | D. A. Anikin I. A. Solovyeva I. V. Demko E. A. Sobko A. Yu. Kraposhina N. V. Gordeeva |
| author_facet | D. A. Anikin I. A. Solovyeva I. V. Demko E. A. Sobko A. Yu. Kraposhina N. V. Gordeeva |
| author_sort | D. A. Anikin |
| collection | DOAJ |
| description | The medical and social significance of cardiovascular diseases remains high. One of the factors that determine cardiovascular risks is metabolic syndrome. As a result of excessive accumulation of lipid and carbohydrate metabolism products in metabolic syndrome, oxidative (oxidative) stress develops. The article considers both domestic and foreign scientific studies, which highlight various aspects of the influence of reactive oxygen and nitrogen species, as well as other free radicals on the formation of oxidative stress in pathological conditions that are part of the metabolic syndrome complex. This describes the mechanisms of the formation of chronic inflammation through excessive secretion of pro-inflammatory cytokines and adipokines, activation of the transcription factor NF-kB, as well as damage to the antioxidant system in obesity. Separately, a number of mechanisms of the stimulating effect of adipokines: leptin, adiponectin, chimerine, omentin 1, resistin, on the formation of oxidative stress have been noted. The ways of activating the polyol pathway, as well as diacyl-glycerol — protein kinase C — the signaling pathway of oxidative stress, the formation of mitochondrial dysfunction is described. As a result of which there is an excessive production of free radicals in insulin resistance, diabetes mellitus and macroand microvascular complications of diabetes. In addition, the influence of oxidative stress directly on the formation of cardiovascular diseases of atherosclerotic genesis, as well as arterial hypertension, has been shown. |
| first_indexed | 2024-03-08T09:11:53Z |
| format | Article |
| id | doaj.art-02e7bf631f084db8a907ae0ce60456ac |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:36:22Z |
| publishDate | 2023-01-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-02e7bf631f084db8a907ae0ce60456ac2024-04-16T16:16:14ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242023-01-0119330631610.14341/omet1280410942Free-radical oxidation as a pathogenetic factor of metabolic syndromeD. A. Anikin0I. A. Solovyeva1I. V. Demko2E. A. Sobko3A. Yu. Kraposhina4N. V. Gordeeva5Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional HospitalThe medical and social significance of cardiovascular diseases remains high. One of the factors that determine cardiovascular risks is metabolic syndrome. As a result of excessive accumulation of lipid and carbohydrate metabolism products in metabolic syndrome, oxidative (oxidative) stress develops. The article considers both domestic and foreign scientific studies, which highlight various aspects of the influence of reactive oxygen and nitrogen species, as well as other free radicals on the formation of oxidative stress in pathological conditions that are part of the metabolic syndrome complex. This describes the mechanisms of the formation of chronic inflammation through excessive secretion of pro-inflammatory cytokines and adipokines, activation of the transcription factor NF-kB, as well as damage to the antioxidant system in obesity. Separately, a number of mechanisms of the stimulating effect of adipokines: leptin, adiponectin, chimerine, omentin 1, resistin, on the formation of oxidative stress have been noted. The ways of activating the polyol pathway, as well as diacyl-glycerol — protein kinase C — the signaling pathway of oxidative stress, the formation of mitochondrial dysfunction is described. As a result of which there is an excessive production of free radicals in insulin resistance, diabetes mellitus and macroand microvascular complications of diabetes. In addition, the influence of oxidative stress directly on the formation of cardiovascular diseases of atherosclerotic genesis, as well as arterial hypertension, has been shown.https://www.omet-endojournals.ru/jour/article/view/12804oxidative stressfree radicalsmetabolic syndromeobesityinsulin resistance |
| spellingShingle | D. A. Anikin I. A. Solovyeva I. V. Demko E. A. Sobko A. Yu. Kraposhina N. V. Gordeeva Free-radical oxidation as a pathogenetic factor of metabolic syndrome Ожирение и метаболизм oxidative stress free radicals metabolic syndrome obesity insulin resistance |
| title | Free-radical oxidation as a pathogenetic factor of metabolic syndrome |
| title_full | Free-radical oxidation as a pathogenetic factor of metabolic syndrome |
| title_fullStr | Free-radical oxidation as a pathogenetic factor of metabolic syndrome |
| title_full_unstemmed | Free-radical oxidation as a pathogenetic factor of metabolic syndrome |
| title_short | Free-radical oxidation as a pathogenetic factor of metabolic syndrome |
| title_sort | free radical oxidation as a pathogenetic factor of metabolic syndrome |
| topic | oxidative stress free radicals metabolic syndrome obesity insulin resistance |
| url | https://www.omet-endojournals.ru/jour/article/view/12804 |
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