Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study
Background: Metastatic tumors are the most common central nervous system (CNS) tumors wherein the primary site remains unknown in most of the cases. Aim: The study was carried out to evaluate metastatic CNS tumors with unknown primary by using simplified diagnostic (clinico-histopathologic) approach...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=3;spage=368;epage=374;aulast=Gupta |
| _version_ | 1817987733941911552 |
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| author | Anshu Gupta Sujata Chaturvedi Deepak Jha Monali Chaturvedi |
| author_facet | Anshu Gupta Sujata Chaturvedi Deepak Jha Monali Chaturvedi |
| author_sort | Anshu Gupta |
| collection | DOAJ |
| description | Background: Metastatic tumors are the most common central nervous system (CNS) tumors wherein the primary site remains unknown in most of the cases. Aim: The study was carried out to evaluate metastatic CNS tumors with unknown primary by using simplified diagnostic (clinico-histopathologic) approach. Material and Methods: A 2 years study was conducted on 32 cases of CNS metastases having unknown primary tumors in a neurosciences institute. Statistical Analysis: All the results were prepared using software version of SPSS 22. Results: The most common metastatic site found in brain was cerebrum (59.3%) [frontal > frontoparietal > parieto-occipital > temporal] [left cerebrum > right cerebrum], followed by cerebellum (12.5%), spinal cord (9.3%), and leptomeninges (3.12%). Most of the metastatic tumors presented as ill-defined (34%) rather than well-defined (22%) lesions with ring enhancement seen only in 16% of the cases on magnetic resonance imaging (MRI).On histopathology findings with targeted immunohistochemistry, most common histological tumor type identified irrespective of site was adenocarcinoma (68.7%), followed by squamous cell carcinoma (15.6%) and poorly differentiated carcinoma (12.5%). Only one case of lymphoma was reported. Corroborating all the above findings along with clinical history and other relevant investigations, primary sites could be detected in 23 cases (71.8%).The most common primary site deduced was lungs (39.1%), followed by thyroid (17.3%), breast in females (13.0%), gastrointestinal tract (8.6%), and prostate in males (4.3%). Only in nine cases (28.1%) with mainly poorly differentiated histopathological type, primary site remained unknown. Conclusion: Detection of the primary site in metastatic CNS tumors is possible by adopting this simple and effective diagnostic approach at centers/hospitals having cost and other constraints. |
| first_indexed | 2024-04-14T00:25:12Z |
| format | Article |
| id | doaj.art-02f032105b14446bae914fef984a60c6 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-14T00:25:12Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-02f032105b14446bae914fef984a60c62022-12-22T02:22:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292019-01-0162336837410.4103/IJPM.IJPM_592_18Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional studyAnshu GuptaSujata ChaturvediDeepak JhaMonali ChaturvediBackground: Metastatic tumors are the most common central nervous system (CNS) tumors wherein the primary site remains unknown in most of the cases. Aim: The study was carried out to evaluate metastatic CNS tumors with unknown primary by using simplified diagnostic (clinico-histopathologic) approach. Material and Methods: A 2 years study was conducted on 32 cases of CNS metastases having unknown primary tumors in a neurosciences institute. Statistical Analysis: All the results were prepared using software version of SPSS 22. Results: The most common metastatic site found in brain was cerebrum (59.3%) [frontal > frontoparietal > parieto-occipital > temporal] [left cerebrum > right cerebrum], followed by cerebellum (12.5%), spinal cord (9.3%), and leptomeninges (3.12%). Most of the metastatic tumors presented as ill-defined (34%) rather than well-defined (22%) lesions with ring enhancement seen only in 16% of the cases on magnetic resonance imaging (MRI).On histopathology findings with targeted immunohistochemistry, most common histological tumor type identified irrespective of site was adenocarcinoma (68.7%), followed by squamous cell carcinoma (15.6%) and poorly differentiated carcinoma (12.5%). Only one case of lymphoma was reported. Corroborating all the above findings along with clinical history and other relevant investigations, primary sites could be detected in 23 cases (71.8%).The most common primary site deduced was lungs (39.1%), followed by thyroid (17.3%), breast in females (13.0%), gastrointestinal tract (8.6%), and prostate in males (4.3%). Only in nine cases (28.1%) with mainly poorly differentiated histopathological type, primary site remained unknown. Conclusion: Detection of the primary site in metastatic CNS tumors is possible by adopting this simple and effective diagnostic approach at centers/hospitals having cost and other constraints.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=3;spage=368;epage=374;aulast=GuptaCentral nervous systemmetastaticprimarytumors |
| spellingShingle | Anshu Gupta Sujata Chaturvedi Deepak Jha Monali Chaturvedi Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study Indian Journal of Pathology and Microbiology Central nervous system metastatic primary tumors |
| title | Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study |
| title_full | Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study |
| title_fullStr | Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study |
| title_full_unstemmed | Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study |
| title_short | Revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings: A single neurosciences institutional study |
| title_sort | revisiting metastatic central nervous system tumors with unknown primary using clinicopathological findings a single neurosciences institutional study |
| topic | Central nervous system metastatic primary tumors |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=3;spage=368;epage=374;aulast=Gupta |
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