Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2009-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/15/9/09-0091_article |
| _version_ | 1818692409705365504 |
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| author | Gelagay Ayelet Mana Mahapatra Esayas Gelaye Berhe G. Egziabher Tesfaye Rufeal Mesfin Sahle Nigel P. Ferris Jemma Wadsworth Geoffrey H. Hutchings Nick J. Knowles |
| author_facet | Gelagay Ayelet Mana Mahapatra Esayas Gelaye Berhe G. Egziabher Tesfaye Rufeal Mesfin Sahle Nigel P. Ferris Jemma Wadsworth Geoffrey H. Hutchings Nick J. Knowles |
| author_sort | Gelagay Ayelet |
| collection | DOAJ |
| description | Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent. |
| first_indexed | 2024-12-17T12:57:20Z |
| format | Article |
| id | doaj.art-02f87a3df8e04b46b6b05746fb00e500 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-17T12:57:20Z |
| publishDate | 2009-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-02f87a3df8e04b46b6b05746fb00e5002022-12-21T21:47:26ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-09-011591409141710.3201/eid1509.090091Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007Gelagay AyeletMana MahapatraEsayas GelayeBerhe G. EgziabherTesfaye RufealMesfin SahleNigel P. FerrisJemma WadsworthGeoffrey H. HutchingsNick J. KnowlesFoot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.https://wwwnc.cdc.gov/eid/article/15/9/09-0091_articleFMD virusserotypephylogenetic treevaccine strainEthiopiaviruses |
| spellingShingle | Gelagay Ayelet Mana Mahapatra Esayas Gelaye Berhe G. Egziabher Tesfaye Rufeal Mesfin Sahle Nigel P. Ferris Jemma Wadsworth Geoffrey H. Hutchings Nick J. Knowles Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 Emerging Infectious Diseases FMD virus serotype phylogenetic tree vaccine strain Ethiopia viruses |
| title | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
| title_full | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
| title_fullStr | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
| title_full_unstemmed | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
| title_short | Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007 |
| title_sort | genetic characterization of foot and mouth disease viruses ethiopia 1981 2007 |
| topic | FMD virus serotype phylogenetic tree vaccine strain Ethiopia viruses |
| url | https://wwwnc.cdc.gov/eid/article/15/9/09-0091_article |
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