Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region

Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region

The killer-cell immunoglobulin-like receptor (KIR) region comprises a fast-evolving family of genes that encode receptors for natural killer (NK) cells and have crucial role in host defense. Evolution of KIR was examined in the context of the human genome. Gene-content diversity and single nucleotid...

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Bibliographic Details
Main Authors: Danillo G. Augusto, Paul J. Norman, Ravi Dandekar, Jill A. Hollenbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
killer cell immunoglobulin-like receptors
evolution
human populations
diversity
pathogens
imputation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00989/full

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